Computational Biology       

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Computational Biology Publications



2015

An Efficient Nonlinear Regression Approach for Genome-Wide Detection of Marginal and Interacting Genetic Variations
S. Lee, A. Lozano, P. Kambadur, and E. P. Xing
19th International Conference on Research in Computational Molecular Biology (RECOMB 2015)

Development and validation of a gene expression tumour classifier for cancer of unknown primary
Richard W Tothill, Fan Shi, Lisa Paiman, Justin Bedo, Adam Kowalczyk, Linda Mileshkin, Evangeline Buela, Robert Klupacs, David Bowtell, Keith Byron
Pathology-Journal of the RCPA 47(1), 7--12, LWW, 2015

ValWorkBench: an open source Java library for cluster validation, with applications to microarray data analysis
R. Giancarlo, D. Scaturro, F. Utro
Computer Methods and Programs in Biomedicine, Elsevier, 2015

Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge
K. Rhrissorrakrai, V. Belcastro, E. Bilal, R. Norel, C. Poussin, C. Mathis, R. H. Dulize, N. V. Ivanov, L. Alexopoulos, J. J. Rice, M. C. Peitsch, G. Stolovitzky, P. Meyer, J. Hoeng
Bioinformatics 31(4), 471--483, 2015

A crowd-sourcing approach for the construction of species-specific cell signaling networks
E. Bilal, T. Sakellaropoulos, I. N. Melas, D. E. Messinis, V. Belcastro, K. Rhrissorrakrai, P. Meyer, R. Norel, A. Iskandar, E. Blaese, J. J. Rice, M. C. Peitsch, J. Hoeng, G. Stolovitzky, L. G. Alexopoulos, C. Poussin
Bioinformatics 31(4), 484--491, 2015

Inter-species prediction of protein phosphorylation in the sbv IMPROVER species translation challenge
M. Biehl, P. Sadowski, G. Bhanot, E. Bilal, A. Dayarian, P. Meyer, R. Norel, K. Rhrissorrakrai, M. D. Zeller, S. Hormoz
Bioinformatics 31(4), 453--461, 2015

Predicting protein phosphorylation from gene expression: top methods from the IMPROVER Species Translation Challenge
A. Dayarian, R. Romero, Z. Wang, M. Biehl, E. Bilal, S. Hormoz, P. Meyer, R. Norel, K. Rhrissorrakrai, G. Bhanot, F. Luo, A. L. Tarca
Bioinformatics 31(4), 462--470, 2015

Inter-species pathway perturbation prediction via data-driven detection of functional homology
C. Hafemeister, R. Romero, E. Bilal, P. Meyer, R. Norel, K. Rhrissorrakrai, R. Bonneau, A. L. Tarca
Bioinformatics 31(4), 501--508, 2015

Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression
R. Kuffner, N. Zach, R. Norel, J. Hawe, D. Schoenfeld, L. Wang, G. Li, L. Fang, L. Mackey, O. Hardiman, M. Cudkowicz, A. Sherman, G. Ertaylan, M. Grosse-Wentrup, T. Hothorn, J. van Ligtenberg, J. H. Macke, T. Meyer, B. Scholkopf, L. Tran, R. Vaughan, G. S
Nat. Biotechnol. 33(1), 51--57, 2015

Host Trait Prediction of Metagenomic Data for Topology-based Visualization
L. Parida, N. Haiminen, D. Haws, J. Suchodolski
Lecture Notes in Computer Science 8956, 134-149 , Springer, 2015
Abstract

High performance computing enabling exhaustive analysis of higher order single nucleotide polymorphism interaction in Genome Wide Association Studies
Benjamin Goudey, Mani Abedini, John L Hopper, Michael Inouye, Enes Makalic, Daniel F Schmidt, John Wagner, Zeyu Zhou, Justin Zobel, Matthias Reumann
Health Information Science and Systems 3(1), 1, BioMed Central, 2015


2014

Resolving ambiguity in genome assembly using high performance computing
Mahtab Mirmomenia, Thomas Conwaya, Matthias Reumannb, Justin Zobelc
Australasia’s big data in biomedicine \& healthcare conference, 36, 2014

The species translation challenge—a systems biology perspective on human and rat bronchial epithelial cells
Carine Poussin, Carole Mathis, Leonidas G Alexopoulos, Dimitris E Messinis, R\'emi HJ Dulize, Vincenzo Belcastro, Ioannis N Melas, Theodore Sakellaropoulos, Kahn Rhrissorrakrai, Erhan Bilal, others
Scientific Data1, Nature Publishing Group, 2014

Inter-species Inference of Gene Set Enrichment in Lung Epithelial Cells from Proteomic and Large Transcriptomic Data Sets
Sahand Hormoz, Gyan Bhanot, Michael Biehl, Erhan Bilal, Pablo Meyer, Raquel Norel, Kahn Rhrissorrakrai, Adel Dayarian
Bioinformatics, btu569, Oxford Univ Press, 2014

Lengths of Orthologous Prokaryotic Proteins Are Affected by Evolutionary Factors
Tatiana Tatarinova, Bilal Salih, Jennifer Dien Bard, Irit Cohen, Alexander Bolshoy
Hindawi, 2014

The Challenges of Systems Biology
Pablo Meyer and Guillermo A. Cecchi
Practical Applications of Sparse Modeling, pp. 7-15, MIT Press, 2014

Reliability Estimation and Enhancement via Spatial Smoothing in Sparse fMRI Modeling
Carroll, Melissa K., Guillermo A. Cecchi, Irina Rish, Rahul Garg, Marwan Baliki, and A. Vania Apkarian
Practical Applications of Sparse Modeling, pp. 123-150, MIT Press, 2014

Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia
Thomas Trimarchi, Erhan Bilal, Panagiotis Ntziachristos, Giulia Fabbri, Riccardo Dalla-Favera, Aristotelis Tsirigos, Iannis Aifantis
Cell 158(3), 593--606, Elsevier, 2014

Comparative exomics of Phalaris cultivars under salt stress
N. Haiminen, M. Klaas, Z. Zhou, F. Utro, P. Cormican, T. Didion, C. Sig Jensen, C.E. Mason, S. Barth, L. Parida
BMC Genomics 15(Suppl 6), S18, BioMed Central Ltd, 2014
Abstract

Redundancy-weighting for better inference of protein structural features
Chen Yanover, Natalia Vanetik, Michael Levitt, Rachel Kolodny, Chen Keasar
Bioinformatics, btu242, Oxford Univ Press, 2014

BAC Sequencing Using Pooled Methods
CA Saski, FA Feltus, L Parida, and N Haiminen
Bacterial Artificial Chromosomes, in Methods in Molecular Biology 1227(3), Springer, 2014
Abstract

Practical Applications of Sparse Modeling
A book edited by I. Rish, G. Cecchi, A.C. Lozano, A. Niculecu-Mizil
MIT Press, 2014

Best-Fit in Linear Time for Non-generative Population Simulation
Niina Haiminen, Claude Lebreton, Laxmi Parida
Algorithms in Bioinformatics, in Lecture Notes in Computer Science 8701, 247-262, Springer, 2014
Abstract

Augmented Human: Human OS for Improved Mental Function
Steve Heisig, Guillermo A. Cecchi, Ravi Rao and Irina Rish
AAAI'14 Workshop on Cognitive Computing for Augmented Human Intelligence, 2014
Abstract

A Window into the Intoxicated Mind? Speech as an Index of Psychoactive Drug Effects
Bedi G, Cecchi G A, Fernandez Slezak D, Carrillo F, Sigman M, de Wit H
Neuropsychopharmacology, 2014
Abstract

Functional gene groups are concentrated within chromosomes, among chromosomes and in the nuclear space of the human genome
Annelyse Thevenin, Liat Ein-Dor, Michal Ozery-Flato, Ron Shamir
Nucleic acids research, gku667, Oxford Univ Press, 2014


2013

Inferring gene expression from ribosomal promoter sequences, a crowdsourcing approach
P. Meyer, G. Siwo, D. Zeevi, E. Sharon, R. Norel, E. Segal, G. Stolovitzky, G. Siwo, A. K. Rider, A. Tan, R. S. Pinapati, S. Emrich, N. Chawla, M. T. Ferdig, Y. A. Tung, Y. S. Chen, M. J. Chen, C. Y. Chen, J. M. Knight, S. M. Sahraeian, M. S. Esfahani, R.
Genome Res. 23(11), 1928--1937, 2013

The Three Steps of Clustering In The Post-Genomic Era
R. Giancarlo, G. Lo Bosco, L. Pinello, F. Utro
Biological Knowledge Discovery Handbook: Preprocessing, Mining, and Postprocessing of Biological Data, pp. 519--556, Wiley Online Library, 2013
Abstract

MINT: Mutual Information based Transductive Feature Selection for Genetic Trait Prediction
D. He, I. Rish, D. Haws, S.Teyssedre, Z. Karaman, L. Parida
The Seventh International Workshop on Machine Learning in Systems Biology (MLSB 2013),
Abstract

Functional MRI Analysis with Sparse Models
I. Rish
Invited paper at NECTAR track of the European Conference on Machine Learning (ECML-2013)
Abstract

sbv IMPROVER Diagnostic Signature Challenge: Design and results
Kahn Rhrissorrakrai, J Jeremy Rice, Stephanie Boue, Marja Talikka, Erhan Bilal, Florian Martin, Pablo Meyer, Raquel Norel, Yang Xiang, Gustavo Stolovitzky, others
Systems Biomedicine 1(4), 3--14, Landes Bioscience, 2013


The genome sequence of the most widely cultivated cacao type and its use to identify candidate genes regulating pod color
J.C. Motamayor, K. Mockaitis, J. Schmutz, N. Haiminen, D. Livingstone, O.E. Cornejo, S. Findley, P. Zheng, F. Utro, S. Royaert, C. Saski, J. Jenkins, R. Podicheti, M. Zhao, B. Scheffler, others
Genome Biology 14(6), R53, BioMed Central Ltd, 2013
Abstract

iXora: Exact haplotype inferencing and trait association
F. Utro, N. Haiminen, D. Livingstone, O.E. Cornejo, S. Royaert, R. Schnell, J.C. Motamayor, D.N. Kuhn, L. Parida
BMC Genetics 14(1), 48, BioMed Central Ltd, 2013
Abstract

BlueSNP: R package for highly scalable genome-wide association studies using Hadoop clusters
H. Huang, S. Tata, R.J. Prill
Bioinformatics 29(1), 135--136, Oxford Univ Press, 2013

Sum of parts is greater than the whole: inference of common genetic history of populations
F. Utro, M. Pybus, L. Parida
BMC Genomics 14(Suppl 1), S10, BioMed Central Ltd, 2013


Evaluation of methods for modeling transcription factor sequence specificity
M.T. Weirauch, A. Cote, R. Norel, M. Annala, Y. Zhao, T.R. Riley, J. Saez-Rodriguez, T. Cokelaer, A. Vedenko, S. Talukder, others
Nature biotechnology, Nature Publishing Group, 2013

Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition
Sarah C Atkinson, Con Dogovski, Matthew T Downton, Peter E Czabotar, Renwick CJ Dobson, Juliet A Gerrard, John Wagner, Matthew A Perugini
Plant molecular biology 81(4-5), 431--446, Springer, 2013


2012

Wisdom of crowds for robust gene network inference
D. Marbach, J.C. Costello, R. Kuffner, N.M. Vega, R.J. Prill, D.M. Camacho, K.R. Allison, The DREAM5 Consortium, M. Kellis, J.J. Collins, G. Stolovitzky
Nature Methods, Nature Publishing Group, 2012

Levodopa and the feedback process on set-shifting in parkinson's disease
W.L. Au, J. Zhou, P. Palmes, Y.Y. Sitoh, L. Tan, J.C. Rajapakse
Human brain mapping, Wiley Online Library, 2012

The folding transition state of Protein L is extensive with non-native interactions (and not small and polarized)
T.Y. Yoo, A. Adhikari, Z. Xia, T. Huynh, K.F. Freed, R. Zhou, T.R. Sosnick
Journal of Molecular Biology, Elsevier, 2012

Stability-Based Model Selection for High Throughput Genomic Data: An Algorithmic Paradigm
R. Giancarlo, F. Utro
Artificial Immune Systems, pp. 260--270, Springer, 2012

GenomicTools: an open source platform for developing high-throughput analytics in genomics
A. Tsirigos, N. Haiminen, E. Bilal, F. Utro
Open source software in life science research: Practical solutions to common challenges in the pharmaceutical industry and beyond, Woodhead Publishing Series in Biomedicine No. 16, 2012

ARG-based genome-wide analysis of cacao cultivars
F. Utro, O.E. Cornejo, D. Livingstone, J.C. Motamayor, L. Parida
BMC Bioinformatics 13(Suppl 19), S17, BioMed Central Ltd, 2012

Slowing and controlling the translocation of DNA in a solid-state nanopore
B. Luan, G Stolovitzky, G Martyna
Nanoscale 4(4), 1068-1077, The Royal Society of Chemistry, 2012

Quantitative modeling of the terminal differentiation of B cells and mechanisms of lymphomagenesis
M. Rodriguez Martinez, A. Corradin, U. Klein, M.J. Alvarez, G.M. Toffolo, B. di Camillo, A. Califano, G.A. Stolovitzky
Proceedings of the National Academy of Sciences 109(7), 2672-2677, 2012

Dynamics of DNA translocation in a solid-state nanopore immersed in aqueous glycerol
B. Luan, D. Wang, R. Zhou, S. Harrer, H. Peng, G. Stolovitzky
Nanotechnology 23(45), 455102, IOP Publishing, 2012


Crystal, solution and in silico structural studies of dihydrodipicolinate synthase from the common grapevine
Sarah C Atkinson, Con Dogovski, Matthew T Downton, F Grant Pearce, Cyril F Reboul, Ashley M Buckle, Juliet A Gerrard, Renwick CJ Dobson, John Wagner, Matthew A Perugini
PLoS One 7(6), e38318, Public Library of Science, 2012

Enzymology of bacterial lysine biosynthesis
Con Dogovski, SC Atkinson, SR Dommaraju, M Downton, L Hor, S Moore, JJ Paxman, MG Pevereli, TW Qiu, M Reumann, others
Biochemistry, pp. 225--262, InTech, 2012

In Silico Cardiac Risk Assessment in Patients With Long QT SyndromeType 1: Clinical Predictability of Cardiac Models
Ryan Hoefen, Matthias Reumann, Ilan Goldenberg, Arthur J Moss, O Jin, Yiping Gu, Scott McNitt, Wojciech Zareba, Christian Jons, Jorgen K Kanters, others
Journal of the American College of Cardiology 60(21), 2182--2191, Am Coll Cardio Found, 2012

Exploiting the brain s network structure in identifying ADHD subjects
Soumyabrata Dey, A.Ravishankar Rao, Mubarak Shah
Frontiers in Systems Neuroscience, Frontiers, 2012

A computational model of early visual cortex using konio-cellular pathway projections
A. Ravishankar Rao, Youping Xiao
International Joint Conference on Neural Networks, pp. 1-8, IEEE, 2012

Hap-seq: An Optimal Algorithm for Haplotype Phasing with Imputation Using Sequencing Data
D. He, B. Han, E. Eskin
Research in Computational Molecular Biology, pp. 64--78, 2012

Industrial methodology for process verification in research (IMPROVER): toward systems biology verification
P. Meyer, J. Hoeng, J. J. Rice, R. Norel, J. Sprengel, K. Stolle, T. Bonk, S. Corthesy, A. Royyuru, M. C. Peitsch, G. Stolovitzky
Bioinformatics 28(9), 1193--1201, 2012


Discovering Patterns in Gene Order
Laxmi Parida, Niina Haiminen
Evolutionary Genomics, in Methods in Molecular Biology 855(3), 431-455, Springer, 2012
Abstract

GenomicTools: a computational platform for developing high-throughput analytics in genomics
A. Tsirigos, N. Haiminen, E. Bilal, F. Utro
Bioinformatics 28(2), 282--283, Oxford University Press, 2012
Abstract

Textual data compression in computational biology: Algorithmic techniques
R Giancarlo, D Scaturro, F Utro
Computer Science Review, Elsevier, 2012

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
P. Ntziachristos, A. Tsirigos, P. Van Vlierberghe, J. Nedjic, T. Trimarchi, M. Sol Flaherty, D. Ferres-Marco, V. da Ros, Z. Tang, J. Siegle, others
Nature medicine 18(2), 298--303, Nature Publishing Group, 2012

Network-Induced Classification Kernels for Gene Expression Profile Analysis
O. Lavi, G. Dror, R. Shamir
Journal of Computational Biology 19(6), 694-709, Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA, 2012

Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents
SE McCormack, O. Shaham, MA McCarthy, AA Deik, TJ Wang, RE Gerszten, CB Clish, VK Mootha, SK Grinspoon, A. Fleischman
Pediatric Obesity, Wiley Online Library, 2012


2011

Extensive protein and DNA backbone sampling improves structure-based specificity prediction for C2H2 zinc fingers
Chen Yanover, Philip Bradley
Nucleic acids research 39(11), 4564--4576, Oxford Univ Press, 2011

Machine learning competition in immunology--Prediction of HLA class I binding peptides
Guang Lan Zhang, Hifzur Rahman Ansari, Phil Bradley, Gavin C Cawley, Tomer Hertz, Xihao Hu, Nebojsa Jojic, Yohan Kim, Oliver Kohlbacher, Ole Lund, others
Journal of immunological methods 374(1), 1--4, Elsevier, 2011

Visualization of single mRNAs reveals temporal association of proteins with microRNA-regulated mRNA
Joseph D Shih, Zeev Waks, Nancy Kedersha, Pamela A Silver
Nucleic acids research 39(17), 7740--7749, Oxford Univ Press, 2011

Cell-to-cell variability of alternative RNA splicing
Zeev Waks, Allon M Klein, Pamela A Silver
Molecular systems biology 7(1), Wiley Online Library, 2011

Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers.
Agnieszka K Witkiewicz, Jessica Kline, Maria Queenan, Jonathan R Brody, Aristotelis Tsirigos, S Pavlides, F Sotgia, MP Lisanti
Cell cycle (Georgetown, Tex.) 10(11), 2011

Structural Properties of the Caenorhabditis elegans Neuronal Network
L. R. Varshney, B. L. Chen, E. Paniagua, D. H. Hall, and D. B. Chklovskii
PLoS Computational Biology 7(2), e1001066, Public Library of Science, 2011

Informational Limits of Neural Circuits
L. R. Varshney and D. Shah
Proceedings of the Forty-Ninth Annual Allerton Conference on Communication, Control, and Computing, pp. 1757-1763, 2011

Neural Reconstruction with Approximate Message Passing (NeuRAMP)
A. K. Fletcher, S. Rangan, L. R. Varshney, and A. Bhargava
Proceedings of the Twenty-Fifth Annual Conference on Neural Information Processing Systems (NIPS), 2011

Speeding up the Consensus Clustering methodology for microarray data analysis
R Giancarlo, F Utro
Algorithms for Molecular Biology 6(1), 1, BioMed Central Ltd, 2011

MULTI-SCALE MODELLING OF BIOSYSTEMS: FROM MOLECULAR TO MESOCALE-Session Introduction.
J Bernauer, S Flores, X Huang, S Shin, R Zhou
Pacific Symposium on Biocomputing, pp. 80, 2011


2010

Functional Information, Biomolecular Messages and Complexity of BioSequences and Structures (Extended Abstract)
D Corona, V Di Benedetto, A Gabriele, R Giancarlo, F Utro
Structure Discovery in Biology: Motifs, Networks & Phylogenies, 2010

Plugging into Proteins: Poisoning Protein Function by a Hydrophobic Nanoparticle
G Zuo, Q Huang, G Wei, R Zhou, H Fang
ACS nano, 1027--1030, ACS Publications, 2010

A New Method to Reconstruct Recombination Events at a Genomic Scale
Marta Melé, Asif Javed, Marc Pybus, Francesc Calafell, Laxmi Parida, Jaume Bertranpetit, The Genographic Consortium
PLoS Comput Biol 6(11), e1001010, Public Library of Science, 2010
Abstract

An Evaluation of Feature Sets and Sampling Techniques for De-identification of Medical Records
James Gardner, Li Xiong, Fusheng Wang, Andrew Post, Joel Saltz, Tyrone Grandison
1st ACM International Health Informatics Symposium, ACM, 2010

The Quality Preserving Database: A Computational Framework for Encouraging Collaboration, Enhancing Power and Controlling False Discovery
E Aharoni, H Neuvirth, S Rosset
IEEE IEEE/ACM Transactions on Computational Biology and Bioinformatics, Published by the IEEE Computer Society, 2010

Recombinomics: population genomics from a recombination perspective
Asif Javed, Laxmi Parida
C3S2E '10: Proceedings of the Third C* Conference on Computer Science and Software Engineering, pp. 129--137, ACM, 2010
Abstract

Prediction of response to antiretroviral therapy by human experts and by the EuResist data-driven expert system (the EVE study)
M. Zazzi, R. Kaiser, A. Sonnerborg, D. Struck, A. Altmann, M. Prosperi, M. Rosen-Zvi, A. Petroczi, Y. Peres, E. Schulter, C. Boucher, F. Brun-Vezinet, R. Harigan, L. Morris, M. Obermeier, C. F. Perno, R. Shafer, A. Vandamme, K. van Laethem, A. Wensing, T.
HIV Medicine pp. 1468-1293, 2010

Single Mutation Effects on Conformational Change and Membrane Deformation of Influenza Hemagglutinin Fusion Peptides
J Li, P Das, R Zhou
The Journal of Physical Chemistry B, 6459--6464, ACS Publications, 2010

Patient-Centric Privacy: Envisioning Collaboration Between Payers, Providers & Patients With The Patient At The Core
Tyrone W A Grandison
the 6th International Conference on Collaborative Computing: Networking, Applications and Worksharing, pp. 1--5, IEEE, 2010

Simulating Collaboration From Multiple, Potentially Non-Collaborative Healthcare Systems To Create A Single View of a Patient
Tyrone W A Grandison, Varun Bhgwan, Daniel Gruhl
the 6th International Conference on Collaborative Computing: Networking, Applications and Worksharing, IEEE, 2010

Antiretroviral Therapy Optimisation without Genotype Resistance
M. CF Prosperi, M. Rosen-Zvi, A. Altmann, M. Zazzi, S. Di Giambenedetto, R. Kaiser, E. Schulter, D. Struck, P. Sloot, D. A. van de Vijver, A. Vandamme, A. Sonnerborg
PLoS ONE 5(10), e13753, Public Library of Science San Francisco, USA, 2010

Medical Content-Based Retrieval for Clinical Decision Support
Tanveer Syeda-Mahmood, James Duncan, Fei Wang, Jayashree Kalpathy-Cramer
Springer-Verlag Berlin Heidelberg, 2010

Cardiac disease detection from echocardiogram using edge filtered scale-invariant motion features
Ritwik Kumar, Fei Wang, David Beymer, Tanveer Syeda-Mahmood
Computer Vision and Pattern Recognition Workshops (CVPRW), 2010 IEEE Computer Society Conference on, pp. 162--169

AALIM: A Cardiac Clinical Decision Support System Powered By Advanced Multi-modal Analytics
D Gruhl, A Amir, D Beymer, G Julia, H Greenspan, A Hobbs, K Pohl, T Syeda-Mahmood, J Terdiman, F Wang
International Medical Informatics Conference (MedInfo), 2010

Molecular Dynamics with Multiple Time Scales: How to Avoid Pitfalls
J A Morrone, R Zhou, BJ Berne
Journal of Chemical Theory and Computation, 1465, ACS Publications, 2010

Unlocking Medical Archives with Multi-Modal Content to Deliver Enhanced Analytics
K Brannon, S Doraiswamy, T Grandison
13th World Congress on Medical and Health Informatics (MEDINFO), 2010

Regulatory Compliance and the Correlation to Privacy Protection in Healthcare
Bhatti R T Grandison
International Journal of Computational Models and Algorithms in Medicine, IGI Global, 2010

Improving Security Policy Coverage in Healthcare
Grandison T R Bhatti
Certification and Security in Health-Related Web applications: Concepts and Solutions, IGI Global, 2010

Enabling Next-Gen Healthcare Services through Evidence-based Medical Integration and Analytics
Gruhl D V Bhagwan T Grandison
19th Annual Frontiers in Service Conference, Citeseer, 2010

WISE Healthcare: Enabling Medical Collaboration in a Web 2.0 World
Grandison T, E Kandogan, V Bhagwan
13th World Congress on Medical and Health Informatics (MEDINFO), Citeseer, 2010

Enabling the Health Internet - Market-Friendly Information Extraction of Online Healthcare Sources
C Grant, T Grandison, A Alba
13th World Congress on Medical and Health Informatics (MEDINFO), Citeseer, 2010

Healthcare Chains - Enabling Application and Data Privacy Controls for Healthcare Information System
E Omran, T Grandison, S A Almaati
13th World Congress on Medical and Health Informatics (MEDINFO), Citeseer, 2010

Privacy for Healthcare Social Networks
E M Maximilien, T Grandison
13th World Congress on Medical and Health Informatics (MEDINFO), Citeseer, 2010

Different sets of QTLs influence fitness variation in yeast
G H Romano, Y Gurvich, O Lavi, I Ulitsky, R Shamir, M Kupiec
Molecular Systems Biology 6(1), Nature Publishing Group, 2010

Towards a rigorous assessment of systems biology models: The DREAM3 challenges
R J Prill, D Marbach, J Saez-Rodriguez, P K Sorger, L G Alexopoulos, X Xue, N D Clarke, G Altan-Bonnet, G Stolovitzky
PLoS ONE 5(2), e9202, Public Library of Science, 2010

Revealing strengths and weaknesses of methods for gene network inference
D Marbach, R J Prill, T Schaffter, C Mattiussi, D Floreano, G Stolovitzky
Proc Natl Acad Sci U S A 107(14), 6286, 2010

Temporal Graphical Models for Cross-Species Gene Regulatory Network Discovery
Y Liu, A Niculescu-Mizil, A Lozano, Y Lu
International conference on Computational Systems Bioinformatics (CSB), 2010

Towards a rigorous assessment of systems biology models: the DREAM3 challenges.
Robert J Prill, Daniel Marbach, Julio Saez-Rodriguez, Peter K Sorger, Leonidas G Alexopoulos, Xiaowei Xue, Neil D Clarke, Gregoire Altan-Bonnet, Gustavo Stolovitzky
PLoS One 5(2), e9202, 2010
Abstract

Revealing strengths and weaknesses of methods for gene network inference.
Daniel Marbach, Robert J Prill, Thomas Schaffter, Claudio Mattiussi, Dario Floreano, Gustavo Stolovitzky
Proc Natl Acad Sci U S A 107(14), 6286--6291, 2010
Abstract


2009

Delimiting subterritories of the human subthalamic nucleus by means of microelectrode recordings and a Hidden Markov Model
A Zaidel, A Spivak, L Shpigelman, H Bergman, Z Israel
Movement Disorders 24(12), 1785--1793, John Wiley \& Sons, 2009

A Cluster Overlap Measure for Comparison of Activations in fMRI Studies
G Cecchi, R Garg, A Rao
Medical Image Computing and Computer-Assisted Intervention--MICCAI 2009, pp. 1018--1025, Springer

An optimization approach to understanding structure-function relationships in the visual cortex
A R Rao, G A Cecchi
Proceedings of the 2009 international joint conference on Neural Networks, pp. 1152--1159

The challenges of systems biology. Preface.
G Stolovitzky, P Kahlem, A Califano
Annals of the New York Academy of Sciences 1158(Annals of the New York Academy o), 2009

Distal Tumors Elicit Distinctive Gene Expression Changes in Mouse Brain Different from Those Induced by Arthritis
M.J. Alvarez, M.C. Salibe, G. Stolovitzky, M. Rubinstein, F.J.Pitossi and O.L. Podhajcer
The Open Neuroscience Journal3, 13-25, 2009


Recognition Mechanism of siRNA by Viral p19 Suppressor of RNA Silencing: A Molecular Dynamics Study
Z Xia, Z Zhu, J Zhu, R Zhou
Biophysical journal 96(5), 1761--1769, Elsevier, 2009



Development and Utilization of a Spatial and Temporal Modeling System to Investigate Disease Outbreaks in Vermont
Hulse, C. L., Conant, J. L., Kaufman, J. H., Edlund, S. B., Ford, D. A.
PHIN 2009, CDC

Temporal and spatial effects of lunar calendar holidays on influenza A transmission in Israel
Kaufman J, Edlund S, Bromberg M, Chodick G, Lessler J, Mesika Yossi, Ram R, Douglas J, Kaufman Z, Levanthal A, Marom R, Shalev V.
Second International Conference on Infectious Diseases Dynamics, Elsevier, 2009

Infectious disease modeling: creating a community to respond to biological threats
Kaufman J, Edlund S, Douglas J.
Statistical Communications in Infectious Diseases 1(1), 1, The Berkeley Electronic Press, 2009

A spatiotemporal model for influenza
Edlund S, Bromberg M, Chodick G, Douglas J, Ford D, Kaufman Z, Lessler J, Marom R, Mesika Y, Ram R, Shalev V, Kaufman J.
HIC 2009, Frontiers of Health Informatics, HIC

Analysis of clinical uncertainties by health professionals and patients: an example from mental health
K Lloyd, M Cella, M Tanenblatt, A Coden
BMC Medical Informatics and Decision Making 9(1), 34, BioMed Central Ltd, 2009

Alu and B1 Repeats Have Been Selectively Retained in the Upstream and Intronic Regions …
ARISTOTELIS TSIRIGOS, I Rigoutsos
domino.research.ibm.com, 2009


Method and apparatus for protein structure analysis
P Athma, AK Royyuru, BD Silverman, R Zhou, P …

Method and apparatus for protein structure analysis
P Athma, A K Royyuru, B D Silverman, R Zhou
US Patent 7,499,805, 2009 - Google Patents, Google Patents
US Patent 7,499,805

Statistical Indices for Computational and Data Driven Class Discovery in Microarray Data
R Giancarlo, D Scaturro, F Utro
Biological Data Mining, pp. 295, Chapman & Hall, 2009

Minimizing recombinations in consensus networks for phylogeographic studies
L Parida, A Javed, M Mel{'e}, F Calafell, J Bertranpetit, others
BMC bioinformatics 10(Suppl 1), S72, BioMed Central Ltd, 2009

Infectious disease modeling: Creating a community to respond to biological threats
J Kaufman, S Edlund, J Douglas
Statistical Communications in Infectious Diseases 1(1), 1, bepress, 2009

Geographical Structure of the Y-chromosomal Genetic Landscape of the Levant: A coastal-inland contrast
M El-Sibai, D E Platt, M Haber, Y Xue, S C Youhanna, R S Wells, H Izaabel, M F Sanyoura, H Harmanani, M A Bonab, others
Annals of human genetics 73(6), 568--581, John Wiley \& Sons, 2009

Investigation of expert rule bases, logistic regression, and non-linear machine learning techniques for predicting response to antiretroviral treatment
M C F Prosperi, A Altmann, M Rosen-Zvi, E Aharoni, G Borgulya, F Bazso, A S{`a}nnerborg, E Schulter, D Struck, G Ulivi, others
Antiviral therapy 14(3), 433--442, International Medical Press, 2009

Sorting cancer karyotypes by elementary operations
M Ozery-Flato, R Shamir
Journal of Computational Biology 16(10), 1445--1460, Mary Ann Liebert, Inc., 2009

Glucose regulates transcription in yeast through a network of signaling pathways
S Zaman, S I Lippman, L Schneper, N Slonim, J R Broach
Molecular Systems Biology 5(1), Nature Publishing Group, 2009

Free energy simulations reveal a double mutant avian H5N1 virus hemagglutinin with altered receptor binding specificity
P Das, J Li, A K Royyuru, R Zhou
Journal of Computational Chemistry 30(11), 1654--1663, Wiley Online Library, 2009

Textual data compression in computational biology: a synopsis
R Giancarlo, D Scaturro, F Utro
Bioinformatics 25(13), 1575, Oxford Univ Press, 2009

Grouped graphical Granger modeling for gene expression regulatory networks discovery
A C Lozano, N Abe, Y Liu, S Rosset
Bioinformatics 25(12), i110, Oxford Univ Press, 2009

Dewetting and Hydrophobic Interaction in Physical and Biological Systems
B J Berne, J D Weeks, R Zhou
Annual review of physical chemistry60, 85--103, Annual Reviews, 2009

Lessons from the DREAM2 Challenges
G Stolovitzky, R J Prill, A Califano
Annals of the New York Academy of Sciences 1158(1), 159--195, Wiley Online Library, 2009

ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes
A A Margolin, T Palomero, P Sumazin, A Califano, A Ferrando, G A Stolovitzky
Proc Natl Acad Sci U S A. 6(106), 244-9 , BioMed Central Ltd, 2009

Lessons from the DREAM2 Challenges.
Gustavo Stolovitzky, Robert J Prill, Andrea Califano
Ann N Y Acad Sci1158, 159--195, 2009
Abstract


2008

Stability Analysis of Mixtures of Mutagenetic Trees
Jasmina Bogojeska, Thomas Lengauer, J\"org Rahnenf\"uhrer
BMC Bioinformatics, 2008

Rtreemix: an R package for estimating evolutionary pathways and genetic progression scores
Jasmina Bogojeska, Adrian Alexa, Andr\'e Altmann, Thomas Lengauer, J\"org Rahnenf\"uhrer
Bioinformatics 24(20), 2391--2392, Oxford Univ Press, 2008

Maximum-Likelihood Estimation of Site-Specific Mutation Rates in Human Mitochondrial DNA …
DF Soria
Hernanz, C Tyler-Smith, AK Royyuru … - Genetics, 2008 - pubmedcentral.nih.gov

Y-chromosomal diversity in Lebanon is structured by recent historical events
P A Zalloua, Y Xue, J Khalife, N Makhoul, L Debiane, D E Platt, A K Royyuru, R J Herrera, D F S Hernanz, J Blue-Smith, others
The American Journal of Human Genetics 82(4), 873--882, Elsevier, 2008


Massively parallel molecular dynamics simulations of lysozyme unfolding
R Zhou, M Eleftheriou, C C Hon, RS Germain, AK Royyuru, BJ Berne
IBM Journal of Research and Development 52(1.2), 19--30, IBM, 2008


2007

The Genographic Project public participation mitochondrial DNA database
DM Behar, S Rosset, J Blue
Smith, O … - PLoS Genet, 2007 - genetics.plosjournals.org

Dead-end elimination for multistate protein design
Chen Yanover, Menachem Fromer, Julia M Shifman
Journal of computational chemistry 28(13), 2122--2129, Wiley Online Library, 2007

Nanopore in metal-dielectric sandwich for DNA position control
S Polonsky, S Rossnagel, G Stolovitzky
Applied Physics Letters 91(15), 153103, 2007
Abstract

Dialogue on Reverse-Engineering Assessment and Methods: The DREAM of High-Throughput Pathway Inference
G Stolovitzky, D Monroe, A Califano
Annals of the New York Academy of Sciences 1115(1), 1--22, Wiley Online Library, 2007

Destruction of long-range interactions by a single mutation in lysozyme
R Zhou, M Eleftheriou, A K Royyuru, B J Berne
Proceedings of the National Academy of Sciences 104(14), 5824, National Acad Sciences, 2007


2006

Magnitude and spatial orientation of the hydrophobic moments of multi-domain proteins
R. Zhou, A. Royyuru, P. Athma, F. Suits
Int J Bioinform Res Appl 2(2), 161--176, 2006


Thermal denaturing of mutant lysozyme with both the OPLSAA and the CHARMM force fields
M Eleftheriou, R S Germain, A K Royyuru, R Zhou
Journal of the American Chemical Society 128(41), 13388--13395, ACS Publications, 2006

Inferring Common Origins from mtDNA
A Royyuru, G Alexe, D Platt, R Vijaya-Satya, L Parida, S Rosset, G Bhanot
Research in Computational Molecular Biology, pp. 246--247, 2006

Deep computing in biology: challenges and progress
A Royyuru
Proceedings of the 15th international conference on …, 2006 - portal.acm.org


2005

Reconstructing biological networks using conditional correlation analysis
J. J. Rice, Y. Tu, G. Stolovitzky
Bioinformatics 21(6), 765--773, 2005


Dynamic properties of network motifs contribute to biological network organization.
Robert J Prill, Pablo A Iglesias, Andre Levchenko
PLoS Biol 3(11), e343, 2005
Abstract


2004

RECOMB2004Currents in Computational Molecular Biology
R Zhou, G Dent, A Royyuru, P Atham
2004 - A. Gramada and PE Bourne, Eds


2003

Spatial profiling of protein hydrophobicity: Native vs. decoy structures
R Zhou, B D Silverman, A K Royyuru, P Athma
Proteins: Structure, Function, and Bioinformatics 52(4), 561--572, John Wiley \& Sons, 2003

Hydrophobicity of protein domains: spatially profiling their distribution
R Zhou, A Royyuru, P Athma, BD Silverman
… and Theoretical Computer Science (DIMACS) Workshop …, 2003


2002

Principles of mucin architecture: structural studies on synthetic glycopeptides bearing …
DM Coltart, AK Royyuru, LJ Williams, PW …
J. Am. Chem. Soc, 2002 - pubs.acs.org

Principles of Mucin Architecture: Structural Studies on Synthetic Glycopeptides Bearing Clustered Mono-, Di-, Tri-, an
DM Coltart, AK Royyuru, LJ Williams, P W Glunz, D Sames, SD Kuduk, JB Schwarz, X
T Chen, SJ Danishefsky, and DH Live, 2002


2001

Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells
U. Klein, Y. Tu, G. Stolovitzky, M. Mattioli, G. Cattoretti, H. Husson, A. Freedman, G. Inghirami, L. Cro, L. Baldini, A. Neri, A. Califano and R. Dalla Favera,
Journal of Experimental Medicine 194(11), 1625, 2001

Blue Gene: a vision for protein science using a petaflop supercomputer
Frances Allen, G Almasi, Wanda Andreoni, D Beece, Bruce J. Berne, A Bright, Jose Brunheroto, Calin Cascaval, J Castanos, Paul Coteus
IBM Systems Journal 40(2), 310-327, IBM, 2001


2000

Insights into glycoproteins: A structural motif for mucins from a glycopeptide
DH Live, RA Kumar, L Williams, D Sames
Peptides for the New Millennium: Proceedings of the …, 2000 - books.google.com

Systematic and fully automated identification of protein sequence patterns
R K Hart, A K Royyuru, G Stolovitzky, A Califano
Journal of Computational Biology 7(3-4), 585--600, 2000

Systematic and automated discovery of patterns in PROSITE families
R Hart, A K Royyuru, G Stolovitzky, A Califano
Proceedings of the fourth annual international conference on Computational molecular biology, pp. 147--154, 2000

Systematic and fully automatic discovery of protein sequence patterns
RK Hart, G Stolovitzky, AK Royyuru, A …
J Comput Biol, 2000