Heng Luo  Heng Luo photo       

contact information

Postdoctoral Researcher - Drug Discovery Technologies
Thomas J. Watson Research Center, Yorktown Heights, NY 10598, USA
  +1dash914dash945dash2041

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Professional Associations

Professional Associations:  International Society for Computational Biology


2016

DPDR-CPI, a server that predicts Drug Positioning and Drug Repositioning via Chemical-Protein Interactome
Heng Luo, Ping Zhang, Xi Hang Cao, Dizheng Du, Hao Ye, Hui Huang, Can Li, Shengying Qin, Chunling Wan, Leming Shi, Lin He, Lun Yang
Scientific Reports6, 35996, Springer Nature, 2016

HLA-B*51:01 is strongly associated with clindamycin-related cutaneous adverse drug reactions
Ying Yang, Sheng-an Chen, Fanping Yang, Lirong Zhang, Gil Alterovitz, Huizhong Zhu, Jiekun Xuan, Xicheng Yang, Heng Luo, Jian Mu, Lin He, Xiaoqun Luo, Qinghe Xing
The Pharmacogenomics Journal0, 1-5, Springer Nature, 2016

sNebula, a network-based algorithm to predict binding between human leukocyte antigens and peptides
Heng Luo, Hao Ye, Hui Wen Ng, Sugunadevi Sakkiah, Donna Mendrick, Huixiao Hong
Scientific Reports6, 32115, Nature Publishing Group, 2016

HLA-B*59:01: a marker for Stevens--Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese
Fanping Yang, Jiekun Xuan, Junyi Chen, Hailei Zhong, Heng Luo, Peng Zhou, Xinghuai Sun, Lin He, Sheng-an Chen, Zhihao Cao, Xiaoqun Luo, Qinghe Xing
The pharmacogenomics journal 16(1), 83--87, Nature Publishing Group, 2016

Homology model and ligand binding interactions of the extracellular domain of the human a4b2 nicotinic acetylcholine receptor
Shu Mao, Hui Wen Ng, Michael Orr, Heng Luo, Hao Ye, Weigong Ge, Weida Tong, Huixiao Hong
Journal of Biomedical Science and Engineering 9(01), 41, Scientific Research Publishing, 2016

Molecular Docking for Identification of Potential Targets for Drug Repurposing
Heng Luo, William Mattes, Donna L Mendrick, Huixiao Hong
Current topics in medicinal chemistry, 2016

Applying network analysis and Nebula (neighbor-edges based and unbiased leverage algorithm) to ToxCast data
Hao Ye, Heng Luo, Hui Wen Ng, Joe Meehan, Weigong Ge, Weida Tong, Huixiao Hong
Environment international89, 81--92, Elsevier, 2016


2015

Machine Learning Methods for Predicting HLA-Peptide Binding Activity
Heng Luo, Hao Ye, Hui Wen Ng, Leming Shi, Weida Tong, Donna Mendrick, Huixiao Hong
Bioinformatics and biology insights 9(Suppl 3), 21, Libertas Academica, 2015

Estrogenic activity data extraction and in silico prediction show the endocrine disruption potential of bisphenol a replacement compounds
Hui Wen Ng, Mao Shu, Heng Luo, Hao Ye, Weigong Ge, Roger Perkins, Weida Tong, Huixiao Hong
Chemical research in toxicology 28(9), 1784--1795, ACS Publications, 2015

Development and validation of decision forest model for estrogen receptor binding prediction of chemicals using large data sets
Hui Wen Ng, Stephen W. Doughty, Heng Luo, Hao Ye, Weigong Ge, Weida Tong, Huixiao Hong
Chemical research in toxicology 28(12), 2343--2351, ACS Publications, 2015

Comparing genetic variants detected in the 1000 genomes project with SNPs determined by the International HapMap Consortium
Wenqian Zhang, Hui Wen Ng, Mao Shu, Heng Luo, Zhenqiang Su, Weigong Ge, Roger Perkins, Weida Tong, Huixiao Hong
Journal of genetics 94(4), 731--740, Springer, 2015

Drug repositioning for diabetes based on 'omics' data mining
Ming Zhang, Heng Luo, Zhengrui Xi, Ekaterina Rogaeva
PLOS ONE 10(5), e0126082, 2015

Understanding and predicting binding between human leukocyte antigens (HLAs) and peptides by network analysis
Heng Luo, Hao Ye, Hui Wen Ng, Leming Shi, Weida Tong, William Mattes, Donna Mendrick, Huixiao Hong
BMC bioinformatics 16(Suppl 13), S9, BioMed Central Ltd, 2015

HLADR: a database system for enhancing the discovery of biomarkers for predicting human leukocyte antigen-mediated idiosyncratic adverse drug reactions
Tingting Du#, Lun Yang#, Heng Luo#, Peng Zhou, Hu Mei, Jiekun Xuan, Qinghe Xing, Baitang Ning, Donna Mendrick, Leming Shi (#: joint first author)
Biomarkers 9(11), 1079--1093, Future Medicine, 2015

Molecular docking to identify associations between drugs and class I human leukocyte antigens for predicting idiosyncratic drug reactions
Heng Luo, Tingting Du, Peng Zhou, Lun Yang, Hu Mei, Hui Wen Ng, Wenqian Zhang, Mao Shu, Weida Tong, Leming Shi, Donna L Mendrick, Huixiao Hong
Combinatorial chemistry & high throughput screening 18(3), 296--304, Bentham Science Publishers, 2015

Comparison of RNA-seq and microarray-based models for clinical endpoint prediction
Wenqian Zhang, Ying Yu, Falk Hertwig, Jean Thierry-Mieg, Wenwei Zhang, Danielle Thierry-Mieg, Jian Wang, Cesare Furlanello, Viswanath Devanarayan, Jie Cheng, Youping Deng, Barbara Hero, Huixiao Hong, Meiwen Jia, Li Li, Simon M Lin, Yuri Nikolsky, et al.
Genome biology 16(1), 1, BioMed Central, 2015


2014

HLA-B*13:01 is associated with salazosulfapyridine-induced drug rash with eosinophilia and systemic symptoms in Chinese Han population
Fanping Yang, Bo Gu, Lirong Zhang, Jiekun Xuan, Heng Luo, Peng Zhou, Qinyuan Zhu, Sijia Yan, Sheng-an Chen, Zhihao Cao, Jinhua Xu, Qinghe Xing, Xiaoqun Luo
Pharmacogenomics 15(11), 1461--1469, Future Medicine, 2014

Competitive molecular docking approach for predicting estrogen receptor subtype a agonists and antagonists
Hui Wen Ng, Wenqian Zhang, Mao Shu, Heng Luo, Weigong Ge, Roger Perkins, Weida Tong, Huixiao Hong
BMC bioinformatics 15(11), 1, BioMed Central, 2014

Whole genome sequencing of 35 individuals provides insights into the genetic architecture of Korean population
Wenqian Zhang, Joe Meehan, Zhenqiang Su, Hui Wen Ng, Mao Shu, Heng Luo, Weigong Ge, Roger Perkins, Weida Tong, Huixiao Hong
BMC bioinformatics 15(11), 1, BioMed Central, 2014

DDI-CPI, a server that predicts drug-drug interactions through implementing the chemical--protein interactome
Heng Luo, Ping Zhang, Hui Huang, Jialiang Huang, Emily Kao, Leming Shi, Lin He, Lun Yang
Nucleic acids research, gku433, Oxford Univ Press, 2014

A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
SEQC/MAQC-III Consortium
Nature biotechnology 32(9), 903--914, Nature Publishing Group, 2014

Haystack, a web-based tool for metabolomics research
Stephen C Grace, Stephen Embry, Heng Luo
BMC bioinformatics 15(11), 1, BioMed Central, 2014

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Ying Yu, James C Fuscoe, Chen Zhao, Chao Guo, Meiwen Jia, Tao Qing, Desmond I Bannon, Lee Lancashire, Wenjun Bao, Tingting Du, Heng Luo, Zhenqiang Su, Wendell D Jones, Carrie L Moland, William S Branham, Feng Qian, Baitang Ning, Yan Li, et al.
Nature communications5, Nature Publishing Group, 2014


2012

FOLDNA, a Web Server for Self-Assembled DNA Nanostructure Autoscaffolds and Autostaples
Chensheng Zhou#, Heng Luo#, Xiaolu Feng, Xingwang Li, Jie Zhu, Lin He, Can Li (#: joint first author)
Journal of Nanotechnology2012, Hindawi Publishing Corporation


2011

DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical--protein interactome
Heng Luo, Jian Chen, Leming Shi, Mike Mikailov, Huang Zhu, Kejian Wang, Lin He, Lun Yang
Nucleic acids research, gkr299, Oxford Univ Press, 2011

Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome - clozapine-induced agranulocytosis as a case study
Lun Yang, Kejian Wang, Jian Chen, Anil G Jegga, Heng Luo, Leming Shi, Chunling Wan, Xizhi Guo, Shengying Qin, Guang He, Guoyin Feng, Lin He
PLoS Comput Biol 7(3), e1002016, Public Library of Science, 2011


2009

SePreSA: a server for the prediction of populations susceptible to serious adverse drug reactions implementing the methodology of a chemical--protein interactome
Lun Yang#, Heng Luo#, Jian Chen, Qinghe Xing, Lin He (#: joint first author)
Nucleic acids research 37(suppl 2), W406--W412, Oxford Univ Press, 2009