For several years I studied the mechanisms of cardiac muscle contraction at the Ural State University in Yekaterinburg, Russia. My work encompassed computational modeling of force generation by isolated cardiac muscles as well as investigating the mechanisms of muscle mechanical coupling. My research activity also involved developing both theoretical and computational frameworks to drive biomechanical experiments on isolated papillary muscles in which the testing apparatus (including actuators and force transducers) was directly guided by a computational model of heart contraction.
In the United States, I extended my expertise to modeling cardiac mechanics at the tissue and organ level in Dr. Trayanova's lab at Johns Hopkins University. My first projects were related to mechano-electrical feedback; in particular, we demonstrated the effect of cardiac mechanics on arrhythmogenesis and defibrillation efficacy. Moving further, my research interests focused on finite element models of ventricular contraction. Our group at JHU developed a 3D electromechanical model of ventricular contraction with anatomically accurate geometries derived from structural imaging data.
At IBM, I’m currently working towards developing a novel class of models of heart mechanics and electrophysiology for assisting the clinical management of complex diseases including arrhythmias, heart failure and hypertrophic cardiomyopathies. By coupling different models that capture the various scales of cardiac biophysics, I am investigating novel strategies to leverage clinical information to simulate course of disease and possible therapeutic outcomes.