For several years I studied the mechanisms of cardiac muscle contraction at the Ural State University, Russia. My work encompassed computational modeling of force generation by isolated cardiac muscle as well as modeling of mechanical coupling between the muscles. Part of my time I spent on developing theoretical and computational tools for the animal experiments in which a computational model of cardiac muscle was mechanically coupled to an isolated papillary muscle of the rabbit or the rat heart preparations.
In the United States, I extended my expertise to modeling of cardiac mechanics on the tissue and organ level in Dr. Trayanova's lab, JHU. My first projects were related to mechano-electrical feedback; in particular, we demonstrated effect of cardiac mechanics on arrhythmogenesis and defibrillation efficacy. Moving further, my research interests focused on finite element models of ventricular contraction. Our group in JHU developed a 3D electromechanical model of ventricular contraction with anatomically accurate geometry derived from structural imaging data. This model was used in a collaborative study with Dr. Elisa E. Konofagou from Columbia University, where the 3D electromechanical model of the ventricles was validated with the experimental method of electromechanical wave imaging.
Recently, I joined IBM, and my goal is to create an advanced high-resolution electromechanical model of ventricular contraction. More about this project you can find in the link “Projects”.