FIDELIO - Bone Health in Diabetes     



FIDELIO - Bone Health in Diabetes - overview

Fidelio Project on bone health in diabetes

FIDELIO is a 4-year research project funded by the EU Framework Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement. Starting in October 2019, 14 ambitious and creative young scientists will be trained to tackle the future challenges of an ageing society.


FIDELIO stands for "Training network for research into bone Fragility In Diabetes in Europe towards a personaLised medIcine apprOach".


It is coordinated by the professors Martina Rauner and Lorenz Hofbauer of the Bone Lab of the Medical Faculty of the TU Dresden. "It will take highly qualified and specially trained scientists and clinicians to develop a new field of research into diabetes and bone. FIDELIO will educate 14 young scientists in an interdisciplinary, intersectoral and international environment and provide them with extensive knowledge and skills across the entire process chain," says Martina Rauner, biotechnologist and professor at the Bone Lab Dresden.

How exactly do type 1 and type 2 diabetes damage the skeleton? What role do inflammatory processes and vascular damage play? Which new therapeutic approaches result from this? How can fractures be more effectively prevented? These are some of the questions that the scientists of the FIDELIO network aim to answer. Using a network of young talents and cooperation with industry, they expect to obtain novel insights into the risk factors and mechanisms of diabetic bone disease. New genetic and diagnostic markers could better identify patients at risk for bone fractures. Imaging techniques are essential for a more precise diagnosis. In collaboration with industry, new imaging-based methods for bone visualization will be developed to ultimately detect bone changes before they lead to fractures.


The researchers and physicians involved in FIDELIO hope to use their findings to develop new prevention and treatment approaches to improve bone quality in people with type 1 and type 2 diabetes mellitus.

Unravelling the diverse interactions and mechanisms of action between glucose, fat and bone metabolism will increase our knowledge of bone health, ultimately allowing us to reduce the fracture burden and increase the quality of life of people with diabetes.

In addition to gaining new scientific knowledge, the EU Marie Skłodowska-Curie  programme aims to support the best scientific minds in Europe at different stages of their careers. As part of this programme, Innovative Training Networks (ITN) undertake innovative and structured training of junior researchers for up to four years, developing their potential to become leading scientists in the future.



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