Antimicrobial Materials @ IBM Research–Almaden     

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James L. Hedrick photoNathaniel Park photo

Antimicrobial Materials @ IBM Research–Almaden Publications



2018

Supramolecular nanofibers self-assembled from cationic small molecules derived from repurposed poly (ethylene teraphthalate) for antibiotic delivery
Shaoqiong Liu, Kazuki Fukushima, Shrinivas Venkataraman, James L Hedrick, Yi Yan Yang
Nanomedicine: Nanotechnology, Biology and Medicine 14(1), 165--172, Elsevier, 2018
Abstract

A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset
W. Chin, G. Zhong, Q. Pu, Chuan Yang, W.Lou, Paola Florez De Sessions, B. Periaswamy, A. Lee, Z.C. Liang, X. Ding, S. Gao, Collins Wenhan Chu, Simone Bianco, Chang Bao, Yen Wah Tong, W.Fan, Min Wu, James L Hedrick, Yiyan Yang L
Nature Communications9, 917, 2018
Abstract


2017

Highly potent antimicrobial polyionenes with rapid killing kinetics, skin biocompatibility and in vivo bactericidal activity
Shaoqiong Liu, Robert J Ono, Hong Wu, Jye Yng Teo, Zhen Chang Liang, Kaijin Xu, Musan Zhang, Guansheng Zhong, Jeremy PK Tan, Michelle Ng, James L. Hedrick
Biomaterials127, 36--48, Elsevier, 2017
Abstract

Broad Spectrum Macromolecular Antimicrobials with Biofilm Disruption Capability and In Vivo Efficacy
Jeremy PK Tan, Daniel J Coady, Haritz Sardon, Alexander Yuen, Shujun Gao, Shaun W Lim, Zhen Chang Liang, Eddy W Tan, Shrinivas Venkataraman, Amanda C Engler, Mareva Fevre, Robert J Ono, Yi Yan Yang, James L Hedrick
Advanced Healthcare Materials 6(16), Wiley Online Library, 2017
Abstract

Highly potent antimicrobial polyionenes with rapid killing kinetics, skin biocompatibility and in vivo bactericidal activity
S Liu, R J Ono, H Wu, J Y Teo, Z C Liang, K Xu, M Zhang, G Zhong, J PK Tan, M Ng, C Yang, J Chan, Z Ji, C Bao, K Kumar, S Gao, A Lee, M Fevre, H Dong, J Y Ying, W Fan, J L Hedrick, YY Yang
Biomaterials127, 36, 2017
Abstract

Preparation of Biodegradable Cationic Polycarbonates and Hydrogels Through the Direct Polymerization of Quaternized Cyclic Carbonates
Alexander Y Yuen, Elena Lopez Martinez, Enrique Gomez-Bengoa, Aitziber L Cortajarena, Robert Hernandez Aguirresarobe, Amaury Bossion, David Mecerreyes, James L Hedrick, Yi Yan Yang, Haritz Sardon
ACS Biomaterials Science and Engineering 3(8), 567-1575, 2017
Abstract


2016

Broad-Spectrum Antimicrobial Star Polycarbonates Functionalized with Mannose for Targeting Bacteria Residing inside Immune Cells
Y32. Chuan Yang, Sangeetha Krishnamurthy, Jie Liu, Shaoqiong Liu, Xiaohua Lu, Daniel J Coady, Wei Cheng, Gennaro De Libero, Amit Singhal, James L Hedrick, Yi Yan Yang,
Advanced Healthcare Materials 5(11), 1272--1281, Wiley Online Library, 2016
Abstract

Tuning the Selectivity of Biodegradable Antimicrobial Cationic Polycarbonates by Exchanging the Counter-Anion
Mehmet Isik, Jeremy PK Tan, Robert J Ono, Ana Sanchez-Sanchez, David Mecerreyes, Yi Yan Yang, James L Hedrick, Haritz Sardon,
Macromolecular Bioscience 16(9), 1360--1367, Wiley Online Library, 2016
Abstract

Antimicrobial coatings against biofilm formation: the unexpected balance between antifouling and bactericidal behavior
Zhi Xiang Voo, Majad, Khan, Xu Qingxing, Narayanan Karthikeyan, Brandon Ng, Raidah Bte Ahmad, James L Hedrick, and Yang, Yi Yan
Polymer Chemistry 7(3), 656--668, Royal Society of Chemistry, 2016
Abstract

Antimicrobial silica particles synthesized via ring-opening grafting of cationic amphiphilic cyclic carbonates: Effects of hydrophobicity and structure
Qingxing Xu, Chuan Yang, James L Hedrick, Yi Yan Yang
Polymer Chemistry 7(12), 2192--2201, Royal Society of Chemistry, 2016
Abstract

Simple and cost-effective polycondensation routes to antimicrobial consumer products
30. Musan Zhang, Jye Jyn Teo, Shaoqiong Liu, Zhen Chang Liang, Xin Ding, Robert J Ono, Gregory Breyta, Amanda C Engler, Daniel J Coady, Jeanette Garcia, Alshakim Nelson, Yi Yan Yang, James L Hedrick,
Polymer Chemistry 7(23), 3923--3932, Royal Society of Chemistry, 2016
Abstract

Design and synthesis of biodegradable grafted cationic polycarbonates as broad spectrum antimicrobial agents
Zhan Yuin Ong, Daniel J. Coady, Jeremy P. K. Tan, Yan Li, Julian M. W. Chan, James L. Hedrick, Yi Yan Yang
Journal of Polymer Science Part A: Polymer Chemistry 54(8), 1029--1035, Wiley Online Library, 2016
Abstract


2015

Design and synthesis of biodegradable cationic graft polycarbonates as broad spectrum antimicrobial agents
Zhan Yuin Ong, Daniel J. Coady, Jeremy P.K. Tan, Yan Li, James L. Hedrick, Yi-Yan Yang
Polymer Chemistry54, 1029, 2015
Abstract

Polyurethane-coated silica particles with broad-spectrum antibacterial properties
Q. Xu, H. Sardon, J. M. W. Chan, J. L. Hedrick, Y. Y. Yang
Polymer Chemistry 6, 2011, 2015
Abstract

Biodegradable Block Copolyelectrolyte Hydrogels for Tunable Release of Therapeutics and Topical Antimicrobial Skin Treatment
R. J. Ono, A. L. Z. Lee, W. Chin, W. S. Goh, A. Y. L. Lee, Y. Y. Yang, J. L. Hedrick
ACS Macro Letters4, 886, 2015
Abstract

Polyurethane-coated silica particles with broad-spectrum antibacterial properties
Qingxing Xu, Haritz Sardon, James L. Hedrick, Yi-Yan Yang
Polymer Chemistry 6(11), 2011-2022, 2015
Abstract

Modular Composite Hydrogels from Cholesterol-Functional Polycarbonates for Antimicrobial Applications
Ashlynn L. Lee, Shrinivas Venkataraman, Courtney Fox, Curtis Frank, James L. Hedrick, Yi Yan Yang
J. Mat. Chem B 3(33), 6953, 2015
Abstract

Broad-spectrum antimicrobial polycarbonate hydrogels with fast degradability
A. Pascual, J. P. Tan, A. Yuen, J. M. Chan, D. J. Coady, D. Mecerreyes, James L. Hedrick, Y. Y. Yang, H. Sardon
Biomacromolecules 16(4), 1169--1178, ACS Publications, 2015
Abstract

Antimicrobial/antifouling polycarbonate coatings: role of block copolymer architecture
Z. X. Voo, M. Khan, K. Narayanan, D. Seah, James L. Hedrick, Y. Y. Yang
Macromolecules 48(4), 1055--1064, ACS Publications, 2015
Abstract

Broad-spectrum antimicrobial/antifouling soft material coatings using poly (ethylenimine) as a tailorable scaffold
Wei Cheng, Chuan Yang, Xin Ding, Amanda C Engler, James L Hedrick, and Yi Yan Yang
Biomacromolecules 16(7), 1967--1977, ACS Publications, 2015
Abstract

Biodegradable Antimicrobial Polycarbonates with In Vivo Efficacy against Multidrug-Resistant MRSA Systemic Infection
J. Cheng, W. Chin, H. Dong, L. Xu, G. Zhong, Y. Huang, L. Li, K. Xu, M. Wu, James. L. Hedrick, Y. Y. Yang, W. Fan,
Advanced Healthcare Materials 4(14), 2128--2136, Wiley Online Library, 2015
Abstract


2014

Enhancement of cationic antimicrobial materials via cholesterol incorporation
Daniel J. Coady, Zhan Yuin Ong, Pei Shan Lee, Shrinivas Venkataraman, Willy Chin, Amanda C. Engler, Yi Yan Yang, James L. Hedrick
Advanced Healthcare Materials 3(6), 882--889, Wiley Online Library, 2014
Abstract

Overcoming Multidrug Resistance in Microbials Using Nanostructures Self-Assembled from Cationic Bent-Core Oligomers
Liu, Shao Qiong and Venkataraman, Shrinivas and Ong, Zhan Yuin and Chan, Julian MW and Yang, Chuan, James L Hedrick, and Yang, Yi Yan
Small 10(20), 4130--4135, Wiley Online Library, 2014
Abstract

Polyurethane-coated silica particles with broad-spectrum antibacterial properties
Qingxing Xu, Haritz Sardon, Julian M.W. Chan, James L. Hedrick, Yi Yan Yang
Polymer Chemistry6, 2011, 2014
Abstract

Brush-Like Polycarbonates Containing Dopamine, Cations and PEG Providing Broad-Spectrum Antibacterial and Antifouling Surface via One-Step Coating
Chuan Yang, Xin Ding, Robert J. Ono, Haeshin Lee, Li Yang Hsu, Yen Wah Tong, James Hedrick, Yi Yan Yang
Advanced Materials26, 7346, 2014
Abstract

Antimicrobial Polycarbonates: Investigating the Impact of Nitrogen-Containing Heterocycles as Quaternizing Agents
Victor Wee Lin Ng, Jeremy Pang Kern Tan, Jiayu Leong, James L. Hedrick, Yi Yan Yang
Macromolecules47, 1285, 2014
Abstract

Antimicrobial polycarbonates: Investigating the impact of nitrogen-containing heterocycles as quaternizing agents
Ng, Victor Wee Lin and Tan, Jeremy Pang Kern and Leong, Jiayu and Voo, Zhi Xiang, James L Hedrick, and Yang, Yi Yan
Macromolecules 47(4), 1285--1291, ACS Publications, 2014
Abstract

Antimicrobial hydrogels: A new weapon in the arsenal against multidrug-resistant infections
Victor W. L. Ng, Julian M. W. Chan, Haritz Sardon, Robert J. Ono, Jeannette M. Garcia, Yi Yan Yang, James L. Hedrick
Advanced Drug Delivery Reviews78, 46--62, Elsevier, 2014
Abstract


2013

Biodegradable broad-spectrum antimicrobial polycarbonates: investigating the role of chemical structure on activity and selectivity
W. Chin, C. Yang, V. Ng, Y. Huang, J. Cheng, Y. W. Tong, D. J. Coady, W. Fan, J. L. Hedrick, Y. Y. Yang
Macromolecules 46(22), 8797--8807, ACS Publications, 2013
Abstract

Supramolecular high-aspect ratio assemblies with strong antifungal activity
Kazuki Fukushima, Shaoqiong Liu, Amanda C. Engler, Daniel J. Coady, Hareem Maune, Jed Pitera, Alshakim Nelson, Nikken Wiradharma, Shrinivas Venkataraman, Yuan Huang, Weimin Fan Yi-Yan Yang, James L. Hedrick
Nature communications4, 2861, Nature Publishing Group, 2013
Abstract

Broad-Spectrum Antimicrobial and Biofilm-Disrupting Hydrogels: Stereocomplex-Driven Supramolecular Assemblies
Y. Li, K. Fukushima, D.J. Coady, A.C. Engler, S. Liu, Y. Huang, J.S. Cho, Y. Guo, L.S. Miller, J.P.K. Tan, others
Angew. Chem. Int. Ed. 52(2), 674--678, Wiley Online Library, 2013
Abstract

Antimicrobial polycarbonates: investigating the impact of balancing charge and hydrophobicity using a same-centered polymer approach
Amanda C. Engler, Jeremy P.K. Tan, Daniel J. Coady, Victor L.N. Wee, Yi Yan Yang, James L. Hedrick
Biomacromolecules 14(12), 4331--4339, ACS Publications, 2013
Abstract

Synergistic Co-Delivery of Membrane-Disrupting Polymers with Commercial Antibiotics against Highly Opportunistic Bacteria
Victor Wee Lin Ng, and Xiyu Ke, Ashlynn Lee, James L. Hedrick, Yi Yan Yang
Advanced Materials 25(46), 6730--6736, Wiley Online Library, 2013
Abstract

Block copolymer mixtures as antimicrobial hydrogels for biofilm eradication
A. L. Z. Lee, V. W. L. Ng, J. L. Hedrick, and Y. Y. Yang
Biomaterials 34(38), 10278--10286, Elsevier, 2013
Abstract


2012

Antimicrobial and antifouling hydrogels formed in situ from polycarbonate and poly (ethylene glycol) via Michael addition
Shao Qiong Liu, 1 Chuan Yang, Kai Jin Xu, Xin Ding, Yuan Huang, Yan Li, Zhong Kang Ji, Wei Min Fan, Lan Juan Li, James L. Hedrick, and Yi Yan Yang
Advanced Materials 24(48), 6484--6489, Wiley Online Library, 2012
Abstract

Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly (ethylene glycol) via Michael Addition
Shao Qiong Liu, Chuan Yang, Yuan Huang, Xin Ding, Yan Li Fan, Wei Min, James L Hedrick
Advanced Materials 24(48), 6484-6489, 2012
Abstract

Broad-Spectrum Antimicrobial and Biofilm Disrupting Hydrogels: Stereocomplex-driven Supramolecular Assemblies
Yan Li, Kazuki Fukushima, Amanda Engler, Daniel J. Coady, Shaoqiong Liu, Yuan Huang, John S. Cho, Yi Guo, Lloyd S. Miller, Pui Lai Rachel Ee, Weimin Fan, Yi Yan Yang, James L. Hedrick
Angew. Chemie Int. Ed., 51, 6, 2012
Abstract

Broad-Spectrum Antimicrobial Supramolecular Assemblies with Distinctive Size and Shape
K. Fukushima, Y.Y. Yang P.A. Korevaar, J.P.K. Tan, J. Pitera, J. A. Nelson, D.J. Coady, J.E. Frommer, A.C. Engler, Y. Huang, K. Xu, Z. Ji, Y. Qiao, W. Fan, L. Li, E.W. Meijer, J.L. Hedrick
ACS Nano 6(10), 9191, 2012
Abstract

Highly dynamic biodegradable micelles capable of lysing Gram-positive and Gram-negative bacterial membrane
Yuan Qiao, Chuan Yang, Daniel J Coady, Zhan Yuin Ong, James L Hedrick, Yi-YanYang
Biomaterials 33(4), 1146--1153, Elsevier, 2012
Abstract

Broad Spectrum Antimicrobial Supramolecular Assemblies with Distinctive Size and Shape
K. Fukushima, J.P.K. Tan, P.A. Korevaar, Y.Y. Yang, J. Pitera, A. Nelson, H. Maune, D.J. Coady, J.E. Frommer, A.C. Engler, James L. Hedrick
ACS Nano 6(10), 9191-9199, ACS Publications, 2012
Abstract


2011

Biodegradable nanostructures with selective lysis of microbial membranes
F. Nederberg, Y. Zhang, J. P. K. Tan, K. Xu, H. Wang, C. Yang, S. Gao, X. D. Guo, K. Fukushima, L. J. Li, J. L. Hedrick, and Y. Y. Yang,
Nature Chemistry 3(5), 409, Nature Publishing Group, 2011
Abstract


2010

Bifunctional hydrogel coatings for water purification membranes: improved fouling resisttance and antimicrobial activity
Y.-H. La, B. D. McCloskey, R. Sooriyakumaran, A. Vora, B. Freeman, M. Nassar, J. L. Hedrick, A. Nelson, R. Allen
J. Membrane Science372, 285, 2010
Abstract