Matthew T Downton  Matthew T Downton photo         

contact information

Research Staff Member
Melbourne Research Laboratory, Melbourne, Australia


Professional Associations

Professional Associations:  American Physical Society (APS)  |  Biophysical Society


A dual role for the N-terminal domain of the IL-3 receptor in cell signalling
Broughton, Sophie E and Hercus, Timothy R and Nero, Tracy L and Kan, Winnie L and Barry, Emma F and Dottore, Mara and Shing, Karen S Cheung Tung and Morton, Craig J and Dhagat, Urmi and Hardy, Matthew P and others
Nature communications 9(1), 386, Nature Publishing Group, 2018


Hydrogen bonds and twist in cellulose microfibrils
Kannam, Sridhar Kumar and Oehme, Daniel P and Doblin, Monika S and Gidley, Michael J and Bacic, Antony and Downton, Matthew T
Carbohydrate Polymers175, 433--439, Elsevier, 2017

Translational diffusion of proteins in nanochannels
S.K. Kannam, M.T. Downton
J. Chem. Phys.146, 054108, 2017


Simulations of Graphitic Nanoparticles at Air-Water Interfaces
G. Yiapanis, A.J. Makarucha, J. Baldauf, M.T. Downton
Nanoscale8, 19620-19628, 2016

Membrane insertion of a dinuclear polypyridylruthenium(II) complex revealed by solid-state NMR and molecular dynamics simulation - implications for selective antibacterial activity
D.K. Weber, M.-A. Sani, M.T. Downton, F. Separovic, F.R. Keene, J.G. Collins
JACS138, 15267-15277, 2016

Size-Dependent Fullerene-Fullerene Interactions in Water: A Molecular Dynamics Study
A.J. Makarucha, J.S. Baldauf, M.T. Downton, G.Y. Yiapanis
J. Phys. Chem. B120, 11018-11025, 2016

Dynamic Modelling Reveals 'Hotspots' on the pathway to Enzyme-Substrate Complex Formation
S.E. Gordon, D.K. Weber, M.T. Downton, J. Wagner, M.A. Perugini
PLOS Computational Biology12, 2016


Gaining insight into cell wall cellulose macrofibril organisation by simulating microfibril adsorption
D.P. Oehme, M.S. Doblin, J. Wagner, A. Bacic, M.T. Downton, M.J. Gidley
Cellulose22, 3501, 2015

Tailoring graphene oxide assemblies by pinning on the contact line of a dissolving microdroplet
H. Yang, Y. Song, M.T. Downton, S. Wang, J. Xu, Z. Hou, X. Zhang
Soft Matter11, 8479, 2015

Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target
S.M. Allen, E.E. Lim, E. Jortzik, J. Preuss, H.H. Chua, J.I. MacRae, S. Rahlfs, K. Häussler, M.T. Downton, M.J. McConville, K. Becker and S.A. Ralph
The FEBS Journal282, 3808, 2015

Characterization of the lipid-binding site of equinatoxin II in micelles by NMR and molecular dynamics simulation
D.K. Weber, S. Yao, N. Rojko, G. Anderluh, T.P. Lybrand, M.T. Downton, J. Wagner, F. Separovic
Biophysical Journal108, 1987, 2015

Novel aspects of the structure and dynamics of I$\beta$ elementary cellulose microfibrils revealed by computational simulations
Daniel P Oehme, Matthew T Downton, Monika S Doblin, John Wagner, Mike J Gidley, Tony Bacic
Plant Physiology, pp--114, Am Soc Plant Biol, 2015


Geometric dependence of the conductance drop in a nanopore due to a particle
Sung Cheol Kim, Sridhar Kumar Kannam, Stefan Harrer, Matthew T Downton, Stephen Moore, John M Wagner
Physical Review E 89(4), 042702, American Physical Society, 2014

Sensing of protein molecules through nanopores: a molecular dynamics study
Sridhar Kumar Kannam, Sung Cheol Kim, Priscilla R Rogers, Natalie Gunn, John Wagner, Stefan Harrer, Matthew T Downton
Nanotechnology 25(15), 155502, IOP Publishing, 2014


Nanosensors for next generation drug screening
Sridhar K Kannam, Matthew T Downton, Natalie Gunn, Sung Cheol Kim, Priscilla R Rogers, Christine Schieber, Julia S Baldauf, John M Wagner, Daniel Scott, Ross Bathgate, others
SPIE Micro+ Nano Materials, Devices, and Applications, pp. 89230I--89230I, 2013

Dimerization of Bacterial Diaminopimelate Epimerase is Essential for Catalysis
Lilian Hor, Renwick CJ Dobson, Matthew T Downton, John Wagner, Craig A Hutton, Matthew A Perugini
Journal of Biological Chemistry, ASBMB, 2013

Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition
Sarah C Atkinson, Con Dogovski, Matthew T Downton, Peter E Czabotar, Renwick CJ Dobson, Juliet A Gerrard, John Wagner, Matthew A Perugini
Plant molecular biology 81(4-5), 431--446, Springer, 2013


Crystal, sSolution and in silico structural studies of dihydrodipicolinate synthase from the common grapevine
Sarah Atkinson, Con Dogovski, Matthew Downton, F Pearce, Cyril Reboul, Ashley Buckle, Juliet Gerrard, Renwick Dobson, John Wagner, Matthew Perugini
PLoS ONE [P] 7(6 (Art. ID: e38318)), 1--9, Public Library of Science, 2012

Enzymology of bacterial lysine biosynthesis
Con Dogovski, SC Atkinson, SR Dommaraju, M Downton, L Hor, S Moore, JJ Paxman, MG Pevereli, TW Qiu, M Reumann, others
Biochemistry, pp. 225--262, InTech, 2012

Crystal, solution and in silico structural studies of dihydrodipicolinate synthase from the common grapevine
Sarah C Atkinson, Con Dogovski, Matthew T Downton, F Grant Pearce, Cyril F Reboul, Ashley M Buckle, Juliet A Gerrard, Renwick CJ Dobson, John Wagner, Matthew A Perugini
PLoS One 7(6), e38318, Public Library of Science, 2012