Laura-Jayne Gardiner  Laura-Jayne Gardiner photo         

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Research Staff Member
Application of ML and Informatics for life sciences
  

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2021

Explainable AI reveals changes in skin microbiome composition linked to phenotypic differences
Carrieri AP, Haiminen N, Maudsley-Barton S, Gardiner LJ, Murphy B, Mayes AE, Paterson S, Grimshaw S, Winn M, Shand C, Hadjidoukas P, Rowe WPM, Hawkins S, MacGuire-Flanagan A, Tazzioli J, Kenny JG, Parida L, Hoptroff M, Pyzer-Knapp EO.
Scientific Reports 11(4565), 2021

Re-purposing software for functional characterization of the microbiome
Gardiner LJ, Haiminen N, Utro F, Parida L, Seabolt E, Krishna R, Kaufman JH
Microbiome 9(4), 2021

Uncovering candidate genes involved in photosynthetic capacity using unexplored genetic variation in Spring Wheat
Ryan Joynson, Gemma Molero, Benedict Coombes, Laura-Jayne Gardiner, Carolina Rivera-Amado, Francisco J Pinera-Chavez, John R Evans, Robert T Furbank, Matthew P Reynolds, Anthony Hall
Plant Biotechnology Journal, 2021


2020

Understanding DNA Methylation Patterns in Wheat
Laura-Jayne Gardiner
Methods of Molecular Biology2093, 33-46, 2020


Hierarchically labeled database indexing allows scalable characterization of microbiomes
F. Utro, N. Haiminen, E. Siragusa, L.-J. Gardiner, E. Seabolt, R. Krishna, J.H. Kaufman, L. Parida
iScience, 2020


A framework for gene mapping in wheat demonstrated using the Yr7 yellow rust resistance gene
Laura Jayne Gardiner, Pauline Bansept-Basler, Mohamed El-Soda, Anthony Hall, Donal M. OSullivan
PLOS ONE 15(4), 2020


2019

Analysis of the recombination landscape of hexaploid bread wheat reveals genes controlling recombination and gene conversion frequency
Laura-Jayne Gardiner, Luzie U. Wingen, Paul Bailey, Ryan Joynson, Thomas Brabbs, Jonathan Wright, James D. Higgins, Neil Hall, Simon Griffiths, Bernardo J. Clavijo, Anthony Hall
Genome Biology, 2019

Next-Generation Sequencing Enabled Genetics in Hexaploid Wheat
Laura-Jayne Gardiner, Ryan Joynson, Anthony Hall
Applications of Genetic and Genomic Research in Cereals, pp. 49-63, 2019

Elucidating the genetic basis of biomass accumulation and radiation use efficiency in spring wheat and its role in yield potential
Gemma Molero, Ryan Joynson, Francisco J. PineraChavez, LauraJayne Gardiner, Carolina RiveraAmado, Anthony Hall, Matthew P. Reynolds
Plant Biotechnology Journal 17(7), 1276-1288, 2019

Integrating genomic resources to present full gene and putative promoter capture probe sets for bread wheat
Laura-Jayne Gardiner, Thomas Brabbs, Alina Akhunov, Katherine Jordan, Hikmet Budak, Todd Richmond, Sukhwinder Singh, Leah Catchpole, Eduard Akhunov, Anthony Hall
GigaScience 8(4), 2019


2018

Hidden variation in polyploid wheat drives local adaptation
Laura-Jayne Gardiner, Ryan Joynson, Jimmy Omony, Rachel Rusholme-Pilcher, Lisa Olohan, Daniel Lang, Caihong Bai, Malcolm Hawkesford, David Salt, Manuel Spannagl, others
Genome research 28(9), 1319--1332, Cold Spring Harbor Lab, 2018

A modified sequence capture approach allowing standard and methylation analyses of the same enriched genomic DNA sample
Lisa Olohan, Laura-Jayne Gardiner, Anita Lucaci, Burkhard Steuernagel, Brande Wulff, John Kenny, Neil Hall, Anthony Hall
BMC genomics 19(1), 250, BioMed Central, 2018


2017

Comparative Mapping and Targeted-Capture Sequencing of the Gametocidal Loci in Aegilops sharonensis
Surbhi Grewal, Laura-Jayne Gardiner, Barobora Ndreca, Emilie Knight, Graham Moore, Ian P. King, Julie King
The Plant Genome 10(2), 1-16, 2017


2016

Mapping-by-sequencing in complex polyploid genomes using genic sequence capture: a case study to map yellow rust resistance in hexaploid wheat
Laura-Jayne Gardiner, Pauline Bansept-Basler, Lisa Olohan, Ryan Joynson, Rachel Brenchley, Neil Hall, Donal M O'sullivan, Anthony Hall
The Plant Journal 87(4), 403--419, 2016


2015

A genome-wide survey of DNA methylation in hexaploid wheat
Laura-Jayne Gardiner, Mark Quinton-Tulloch, Lisa Olohan, Jonathan Price, Neil Hall, Anthony Hall
Genome biology 16(1), 273, BioMed Central, 2015

A haplotype map of allohexaploid wheat reveals distinct patterns of selection on homoeologous genomes
Katherine W Jordan, Shichen Wang, Yanni Lun, Laura-Jayne Gardiner, Ron MacLachlan, Pierre Hucl, Krysta Wiebe, Debbie Wong, Kerrie L Forrest, Andrew G Sharpe, others
Genome biology 16(1), 48, BioMed Central, 2015


2014

New technologies for high throughput genetic analysis of complex genomes
Laura-Jayne Gardiner
Ph.D. Thesis, 2014

Using genic sequence capture in combination with a syntenic pseudo genome to map a deletion mutant in a wheat species
Laura-Jayne Gardiner, Piotr Gawro\'nski, Lisa Olohan, Thorsten Schnurbusch, Neil Hall, Anthony Hall
The Plant Journal 80(5), 895--904, 2014


2013

CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia
Gillian G. Johnson, Ke Lin, Trevor F. Cox, Melanie Oates, David R. Sibson, Richard Eccles, Bryony Lloyd, Laura-Jayne Gardiner, Daniel F. Carr, Munir Pirmohamed, Jonathan C. Strefford, David G. Oscier, David Gonzalez de Castro, Monica Else, Daniel Catovsky, Andrew R. Pettitt
Blood 122(26), 4253-4258, 2013