Govind Kaigala  Govind Kaigala photo         

contact information

Research Staff Member
IBM Research Laboratory - Zurich, Rueschlikon, Switzerland



Quantification of tumor heterogeneity: from data acquisition to metric generation
Kashyap, A., Rapsomaniki, M., Fomitcheva Khartchenko, A., Barros, V., Martinelli, A. L., Foncubierta Rodriguez, A., Gabrani, M., Rosen-Zvi, M., Kaigala, G.V.,
Trends in Biotechnology, 2022.


Reconfigurable microfluidics
Paratore, F., Bacheva, V., Bercovici, M., and Kaigala, G. V.,
Nature Reviews Chemistry, 2021.

Local protein heterogeneity analysis in frozen tissues to evaluate tumor heterogeneity
Fomitcheva Khartchenko, A. Rapsomaniki, M., Bettina S., and Kaigala, G. V.
PLoS One, 2021.

Biopatterning: The Art of Patterning Biomolecules on Surfaces
Delamarche, E., Pereiro, I., Kashyap, A., Kaigala, G.V.,
Langmuir, 2021.

Advection-enhanced kinetics in microtiter plates for improved surface assay quantitation and multiplexing capabilities
Pereiro, I., Fomitcheva Khartchenko, A., Lovchik, R., Kaigala, G.V.,
Angewandte Chemie International Edition, 2021.

Mapping Spatial Genetic Landscapes in Tissue Sections through Microscale Integration of Sampling Methodology into Genomic Workflows
von Voithenberg, L., Kashyap, A., Opitz, L., Aquino, C., Sykes, T., Nieser, M., Petrini, L. F. T., Casimiro, N. E., van Kooten, X. F., Biskup, S., Schlapbach, R., Schraml, P. and Kaigala, G. V.,
Small, 2021.

Micro-scale technologies propel biology and medicine
Pereiro, I., Aubert, J. and Kaigala, G. V.,
Biomicrofluidics 15(2), 2021.

Biointegrated Fluidic Milling
Widerker, D., Paratore, P., Bercovici, M., and Kaigala, G.V.,
Advanced Materials Technologies 6(2), 2021.



Rapid micro-immunohistochemistry
Lovchik, R., Taylor, D., and Kaigala, G. V.
Microsystems & Nanoengineering, 2020.

Open space diffusive filter for simultaneous species retrieval and separation
Mathur, M., Khartchenko, A. F., deMello, A., and Kaigala, G.V.
Analytical Chemistry, 2020.

Shake it or flow it: Mass transport and kinetics in surface bioassays using agitation and microfluidics
Pereiro, I., Khartchenko, A. F., and Kaigala, G. V.  
Analytical Chemistry, 2020.

Diffusion-based separation using bidirectional electroosmotic flow
Bacheva, V., Paratore, F., Rubin, S., Kaigala, G. V., and Bercovici, M.
Angewandte Chemie International Edition, 2020.

[ Blog ]

Reconfigurable Microfluidics: Real-time shaping of virtual channels through hydrodynamic forces
Taylor, D., and Kaigala, G. V.
Lab on a Chip, 30, 1720-1728, 2020.

[ Blog ]

Electrokinetic Scanning Probe
Ostromohov, N., Rofman, B., Bercovici, M., and Kaigala, G. V.
Small, 2020.

Voithenberg, L. V., Huber, D., Khartchenko, A. F., Schraml, P., and Kaigala, G. V.
Nucleic Acids Research, 2019.

Spatially resolved genetic analysis of tissue sections enabled by microscale flow confinement retrieval and isotachophoretic purification
van Kooten,X., Petrini, L. F. T., Kashyap, A. von Voithenberg, L. V., Bercovici, M. and Kaigala, G. V.
Angewandte Chemie International Edition, 2019.


Electroosmotic Flow Dipole: Experimental Observation and Flow Field Patterning
Paratore, F., Boyko, E., Kaigala,, G. V., and Bercovici, M.
Physical Review Letters, 122, 224502, 2019.

Nip the bubble in the bud: a guide to avoid gas nucleation in microfluidics
Pereiro, I., Fomitcheva Khartchenko, A., Petrini, P., and Kaigala, G.V.
Lab on a Chip, 2019.

[ movie ]

[ Blog ]

Dynamic microscale flow patterning using electrical modulation of zeta potential
Paratore, F., Bacheva, V., Kaigala, G.V., and Bercovic, M.
Proceedings of the National Academy of Sciences, 2019.

[ Blog ] [ Physics World article ]

Quantitative microimmunohistochmiestry for the grading of immunostains on tumor tissues
Kashyap, A.; Fomitcheva Khartchenko, A.; Pati, P; Gabrani, M; Schraml, P; and Kaigala, G.V.
Nature Biomedical Engineering, 2019.

[ Nature Blog ]  [ IBM Blog ] [ Lead authors Blog ]

High-Quality Immunohistochemical Stains through Computational Assay Parameter Optimization
Arar, N. M. ; Pati, P., Kashyap, P. ; Fomitcheva Khartchenko, A., Goksel, O., Kaigala, G. V., Gabrani, M.
IEEE Transaction on Biomedical Engineering, 2019.

[ movie ]

Underpinning transport phenomena for the patterning of biomolecules
I. Pereiro, J. F. Cors, S. Pane, B. J. Nelson, and G. V. Kaigala,
Chemical Society Reviews, Vol. 48, Number 5, 2019.

[ Blog ]

Fluidic bypass structures for improving the robustness of liquid scanning probes
D. Taylor and G. V. Kaigala
IEEE Transactions on Biomedical Engineering, 2019.


Fluorescence in situ hybridization (FISH): History, limitations and what to expect from micro-scale FISH?
D. Huber, L. Voith von Voithenberg, and G.V. Kaigala
Micro and Nano Engineering, 2018.


Extraction of electrokinetically separated analytes with on-demand encapsulation
X.F. van Kooten, M. Bercovici, G.V. Kaigala
Lab on a Chip, 2018.


  • selected as HOT article.
N. Ostromohov, D. Huber, M. Bercovici, and  G.V. Kaigala
Analytical Chemistry 90, 11169-11734, 2018.
Rapid micro fluorescence in situ hybridization in tissue sections
D. Huber, G.V. Kaigala
Biomicrofluidics 12(4) 042212, 2018.
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Analyte-localization device for point-of-use processing of sub-millimetre areas on surfaces
A. Oskooei, G.V. Kaigala
Sensors and Actuators B: Chemical 258, 961-969, 2018.
Toward microscale flow control using non-uniform electro-osmotic flow
F. Paratore, E. Boyko, A.D. Gat, G.V. Kaigala, M. Bercovici
Proc. SPIE 10491, Microfluidics, BioMEMS, Medical Microsystems XVI, 104910P, 2018.
Hydrodynamics in Cell Studies
D. Huber, A. Oskooei, X.C. Solvas, A. deMello, G.V. Kaigala
Chemical Reviews 118(4) 2042–2079, 2018.
[ Blog ]
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Focusing analytes from 50uL into 500 pL: On-chip focusing from large sample volumes using isotachophoresis
X.F. van Kooten, M. Truman-Rosentsvit, G.V. Kaigala, M. Bercovici
Scientific Reports 7, 2017.
Computational Immunohistochemistry: Recipes for Standardization of Immunostaining
M. Arar, P. Pushpak, A. Kashyap, A. Fomitcheva Khartchenko O. Goksel, G.V. Kaigala, M. Gabrani,
Proc. International Conf. on Medical Image Computing and Computer-Assisted Intervention “MICCAI,” pp. 48055, 2017.
Isotachophoresis-Based Surface Immunoassay
F. Paratore, T. Zeidman Kalman, T. Rosenfeld, G.V. Kaigala, M. Bercovici
Analytical Chemisty 89(14), 7373-7381, 2017.
[ Blog ]
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Tissue Lithography: Microscale Dewaxing to Enable Retrospective Studies on Formalin-Fixed Paraffin Embedded (FFPE) Tissue Sections
J.F. Cors, A. Kashyap, A. Fomitcheva Khartchenko, P. Schraml, G.V. Kaigala
PLoS One, 2017.


Hydrodynamic thermal confinement: creating thermo-chemical microenvironments on surfaces
J.F. Cors, A. Stucki, G. V. Kaigala
Chemical Communications 52, 13035-13038, 2016.
Centimeter-scale surface interactions using hydrodynamic flow confinements
D.P. Taylor, I. Zeaf, R. D. Lovchik, G.V. Kaigala
Langmuir 32(41), 10537-10544, 2016.
Rapid subtractive patterning of live cell layers with a microfluidic probe
A. Kashyap, J.C. Cors, R.D. Lovchik, G.V. Kaigala
Journal of Visualized Experiments 115, e54447, 2016.
Selective local lysis and sampling of live cells for nucleic acid analysis using a microfluidic probe
A. Kashyap, J. Autebert, E. Delamarche, G.V. Kaigala
Scientific Reports 6, 29579, 2016.


Delivery of minimally dispersed liquid interfaces for sequential surface chemistry
N. Ostromohov, M. Bercovici, G.V. Kaigala
Lab on a Chip 16, 3015-3023, 2016.
  • Special issue on emerging investigators

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Convection-enhanced biopatterning with hydrodynamically confined nanoliter volumes of reagents
J. Autebert, J. Cors, D. Taylor, G.V. Kaigala
Analytical Chemistry 88(6), 3235-3242, 2016.

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Micro fluorescence in situ hybridization (µFISH) for spatially multiplexed analysis of a cell monolayer
D. Huber, J. Autebert, G.V. Kaigala
Biomedical Microdevices 18(40), 2016.


Passive removal of immiscible spacers from segmented flows in a microfluidic probe
X.F. Kooten, J. Autebert, G.V. Kaigala
Applied Physics Letters 106, 074102, 2015.
Lab-on-a-chip devices. How to close and plug the lab?
Y. Temiz, R.D. Lovchik, G.C. Kaigala, E. Delamarche
Microelectronic Engineering 132, 156-175, 2015.



The floating Microfluidic Probe (fMFP): Distance control between probe and sample using hydrodynamic levitation
M. Hitzbleck, G.V. Kaigala, E. Delamarche, R.D. Lovchik
Applied Physics Letters 104, 263501, 2014.
A compact and versatile microfluidic probe for local processing of tissue sections and biological specimens
J.F. Cors, R.D. Lovchik, E. Delamarche, G.V. Kaigala
Review of Scientific Instruments 85, 034301, 2014.
Hierarchical hydrodynamic flow confinement: efficient use and retrieval of chemicals for microscale biochemistry on surfaces
J. Autebert, A. Kashyap, R.D. Lovchik, E. Delamarche, G.V. Kaigala
Langmuir 30(12), 2014.


G.V. Kaigala, R.D. Lovchik, E. Delamarche
Angewandte Chemie 51(45) 11224-11240, 2012.
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Micro-immunohistochemistry using a microfluidic probe
R.D. Lovchik, G.V. Kaigala, M. Georgiadis, E. Delamarche
Lab on a Chip 12, 1040-1043, 2012.

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Nonlinear controller designs for thermal management in PCR amplification
J. Jiang, G.V. Kaigala, H.J. Marquez, C.J. Backhouse
IEEE Transactions on Control System Technology 20(1), 11-30, 2012.



G.V. Kaigala, R.D. Lovchik, U. Drechsler, E. Delamarche
Langmuir 27, 5686-5693, 2011.
Rapid detection of urinary tract infection using and isotachaphoresis and molecular beacons
M. Bercovici, G.V. Kaigala (co-first author), K. Mach, C. Han, J. Liao, J.G. Santiago
Analytical Chemistry 83, 4110-4117, 2011.
Electrophoresis 32, 563-572, 2011.


Miniaturized system for isotachophoresis assays
G.V. Kaigala, M. Bercovici, M. Behnam, D. Elliott, J.G. Santiago, C.J. Backhouse
Lab on a Chip 10, 2242-2250, 2010.
Method for analyte identification using isotachophoresis and a fluorescent carrier ampholytes assay
M. Bercovici, G.V. Kaigala, J.G. Santiago
Analytical Chemistry 82, 2134-2138, 2010.
Fluorescent carrier ampholytes assay for portable, label-free detection of chemical toxins in tap water
M. Bercovici, G.V. Kaigala, C.J. Backhouse, J.G. Santiago
Analytical Chemistry 82, 1858-1866, 2010.
G.V. Kaigala, M. Behnam, A.C.E. Bidulock, C. Bargen, R.W. Johnstone, D.G. Elliott, C. J. Backhouse
The Analyst 7, 1606-1617, 2010.

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Integrated circuit-based instrumentation for microchip capillary electrophoresis
M. Behnam, G.V. Kaigala (co-first author), M. Khorasani, S. Martel, D.G. Elliott, C.J. Backhouse
IET Nanobiotechnology 4, 91-101, 2010.
System design and modeling of a time-varying nonlinear temperature controller for microfluidics
G.V. Kaigala, J. Jiang, C.J. Backhouse, H.J. Marquez
IEEE Transactions on Control System Technology 18, 521-530, 2010.


Inexpensive, universal serial bus-powered and fully portable lab-on-a-chip-based capillary electrophoresis instrument
G.V. Kaigala, M. Behnam, C. Bliss, M. Khorasani, S. Ho, D.G. Elliott, J. McMullin, C.J. Backhouse
IET Nanobiotechnology 3, 1-7, 2009.


Strategies for enhancing the speed and integration of microchip genetic amplification
V.N. Hoang, G.V. Kaigala, A. Atrazhev, L.M. Pilarski, C.J. Backhouse
Electrophoresis, 29, 4684-4694, 2008,
Elemental analysis using micro Laser-induced Breakdown Spectroscopy (micro-LIBS) in a microfluidic platform
Y. Godwal, G.V. Kaigala (co-first author), V. Hoang, S-L. Lui, C. Backhouse, Y. Tsui, R. Fedosejevs
Optics Express 16, 12435-12445, 2008.
  •  selected for publication in the Virtual Journal of Biomedical Optics.
An integrated CMOS high voltage supply for true Lab-on-a-Chip
M. Behnam, G.V. Kaigala, M. Khorasani, P. Marshall, C.J. Backhouse, D.G. Elliott
Lab on a Chip 8, 1524-1529, 2008.
G.V. Kaigala, V. Hoang, C.J. Backhouse
Lab on a Chip 8, 1071-1078, 2008.

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Readily integrated, electrically-addressable microvalves
W.H. Song, J. Kwan, G.V. Kaigala, V.N. Hoang and C.J. Backhouse
Journal of Micromechanics and Microengineering 18, 045009, 2008.
G.V. Kaigala, V. Hoang, A. Stickel, J. Lauzon, D. Manage, L.M. Pilarski, C.J. Backhouse
The Analyst 133, 331-338, 2008.
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Dynamic temperature measurement in microfluidic devices using thermochromic liquid crystals
V. Hoang, G.V. Kaigala, C.J. Backhouse
Lab on a Chip 8, 484-487, 2008.



Microfluidic platform for Single Nucleotide Polymorphism genotyping of the Thiopurine S-Methyltransferase gene to evaluate risk for adverse drug events
J. Chowdhury, G.V. Kaigala (co-first author), S. Pushpakom, J. Lauzon, A. Makin, A. Atrazhev, A. Stickel, W. G. Newman, C.J. Backhouse, L.M. Pilarski
Journal Molecular Diagnostics 9, 521-529, 2007.
Microfluidic chips for detecting the t(4;14) translocation and monitoring disease during treatment using Reverse Transcriptase-Polymerase Chain Reaction analysis of IgH-MMSET hybrid transcripts
J. Van Dijken, G.V. Kaigala (co-first author), J. Lauzon, A. Atrazhev, B.J. Taylor, T. Reiman, A.R. Belch, C.J. Backhouse, L.M. Pilarski
Journal of Molecular Diagnostics 9, 358-367, 2007 .
FISH and chips: Chromosomal analysis on microfluidic platforms
V.J. Sieben, C.S. Debes-Marun, P.M. Pilarski, G.V. Kaigala, L.M. Pilarski, C.J. Backhouse
IET Nanobiotechnology 1, 25-37, 2007.
G.V. Kaigala, S. Ho, R. Penterman, C.J. Backhouse
Lab on a Chip 7, 384-387, 2007.



Automated screening using microfluidic chip-based PCR and product detection to assess risk of BK virus-associated nephropathy in renal transplant recipients
G.V. Kaigala, R. Huskins, J. Preiksaitas, X. Pang, L.M. Pilarski, C.J. Backhouse
Electrophoresis 27, 3753, 2006.