Govind Kaigala  Govind Kaigala photo         

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Research Staff Member
IBM Research Laboratory - Zurich, Rueschlikon, Switzerland
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Representative videos from recent published work

Local protein heterogeneity analysis in frozen tissues to evaluate tumor heterogeneity
Fomitcheva Khartchenko, A. Rapsomaniki, M., Bettina S., and Kaigala, G. V.
PLoS One, 2021.


Advection-enhanced kinetics in microtiter plates for improved surface assay quantitation and multiplexing capabilities
Pereiro, I., Fomitcheva Khartchenko, A., Lovchik, R., Kaigala, G.V.,
Angewandte Chemie International Edition, 2021.


Micro-scale technologies propel biology and medicine
Pereiro, I., Aubert, J. and Kaigala, G. V.,
Biomicrofluidics 15(2), 2021.


Mapping Spatial Genetic Landscapes in Tissue Sections through Microscale Integration of Sampling Methodology into Genomic Workflows
von Voithenberg, L., Kashyap, A., Opitz, L., Aquino, C., Sykes, T., Nieser, M., Petrini, L. F. T., Casimiro, N. E., van Kooten, X. F., Biskup, S., Schlapbach, R., Schraml, P. and Kaigala, G. V.,
Small, 2021.


Biointegrated Fluidic Milling
Widerker, D., Paratore, P., Bercovici, M., and Kaigala, G.V.,
Advanced Materials Technologies 6(2), 2021.


R. D. Lovchik, D. Taylor, and G. V. Kaigala,
Rapid Immunohistochemistry
Microsystems and Nanoengineering, 2020.
DOI: https://www.nature.com/articles/s41378-020-00205-2


P. Mathur, A. F. Khartchenko, A. deMello and G. V. Kaigala,
Open Space Diffusive Filter for Simultaneous Species Retrieval and Separation
Analytical Chemistry, 2020.
DOI: https://pubs.acs.org/doi/10.1021/acs.analchem.0c02176


I. Pereiro, A. F. Khartchenko and G. V. Kaigala
Shake it or flow it: Mass transport and kinetics in surface bioassays using agitation and microfluidics
Analytical Chemistry, 2020.
DOI: https://pubs.acs.org/doi/abs/10.1021/acs.analchem.0c01625

 


D. Taylor and G. V. Kaigala
“Reconfigurable Microfluidics: Real-time shaping of virtual channels through hydrodynamic forces “
Lab on a Chip, 30, 1720-1728, 2020.
DOI: https://doi.org/10.1039/D0LC00197J

[ Blog ]


V. Bacheva, F. Paratore, S. Rubin, G.V. Kaigala, M. Bercovici
“Diffusion-based separation using bidirectional electroosmotic flow”
Angewandte Chemie International Edition, 2020.
DOI: 10.1002/anie.201916699

[ Blog ]


N. Ostromohov, B. Rofman, M. Bercovici, G.V. Kaigala
“Electrokinetic Scanning Probe”
Small, 2020.
DOI: 10.1002/smll.201904268


L. V. Voithenberg, D. Huber, A. F. Khartchenko, P. Schraml, G. V. Kaigala
“Spatially multiplexed RNA in situ hybridization to reveal tumor heterogeneity”
Nucleic Acids Research, 2019.
DOI: https://doi.org/10.1093/nar/gkz1151


X. van Kooten, L.F.T. Petrini, A. Kashyap, L.V. von Voithenberg, M. Bercovici, G.V. Kaigala 
“Spatially resolved genetic analysis of tissue sections enabled by microscale flow confinement retrieval and isotachophoretic purification”
Angewandte Chemie International Edition, 2019.
DOI: 10.1002/anie.201907150

[ Blog ]


I. Pereiro, A. Fomitcheva Khartchenko, P. Petrini, G.V. Kaigala
“Nip the bubble in the bud: a guide to avoid gas nucleation in microfluidics”
Lab on a Chip, 2019.
DOI: 10.1039/C9LC00211A

[ Blog ]


F. Paratore, E. Boyko, G. V. Kaigala, M. Bercovici
“Electroosmotic Flow Dipole: Experimental Observation and Flow Field Patterning”
Physical Review Letters, 2019.
DOI: 10.1103/PhysRevLett.122.224502


A. Kashyap, A. Fomitcheva Khartchenko, P. Pati, M. Gabrani, P. Schraml, G.V. Kaigala
“Quantitative microimmunohistochmiestry for the grading of immunostains on tumor tissues”
Nature Biomedical Engineering, 2019.
DOI: 10.1038/s41551-019-0386-3

[ Nature Blog ] [ IBM Blog ] [ Lead authors Blog ]


F. Paratore, V. Bacheva, G.V. Kaigala, M. Bercovici
“Dynamic microscale flow patterning using electrical modulation of zeta potential”
Proceedings of the National Academy of Sciences, 2019.
DOI: 10.1073/pnas.1821269116

[ Blog ] [ Physics World ]


N.M. Arar, P. Pati, P. Kashyap, A. Fomitcheva Khartchenko, O. Goksel, G.V. Kaigala, M. Gabrani,
“High-Quality Immunohistochemical Stains through Computational Assay Parameter Optimization”
IEEE Transactions on Biomedical Engineering, 2019.
DOI: 10.1109/TBME.2019.2899156


D. Taylor, G.V. Kaigala
“Fluidic bypass structures for improving the robustness of liquid scanning probes”
IEEE Transactions on Biomedical Engineering, 2019.
DOI: 10.1109/TBME.2018.2890602


I. Pereiro, J.F. Cors, S. Pané, B.J. Nelson, G.V. Kaigala
“Underpinning transport phenomena for the patterning of biomolecules”
Chem. Soc. Rev. 5, 2019.
DOI: 10.1039/C8CS00852C

[ Blog ]


N. Ostromohov, D. Huber, M. Bercovici, G.V. Kaigala
“Real-time monitoring of fluorescence in situ hybridization kinetics”
Analytical Chemistry 90, 11169-11734, 2018.

DOI: 10.1021/acs.analchem.8b02630

[ Blog ]


A. Kashyap, J. Autebert, E. Delamarche, G.V. Kaigala
“Selective local lysis and sampling of live cells for nucleic acid analysis using a microfluidic probe” 
Scientific Reports 6, 29579, 2016.

DOI: 10.1038/srep29579




N. Ostromohov, M. Bercovici and G.V. Kaigala
“Delivery of minimally dispersed liquid interfaces for sequential surface chemistry”
Lab on a Chip 16, 3015–3023, 2016.
DOI: 10.1039/C6LC00473C


J.F. Cors, A. Kashyap, A. Fomitcheva Khartchenko, P. Schraml, G.V. Kaigala
“Tissue Lithography: Microscale Dewaxing to Enable Retrospective Studies on Formalin-Fixed Paraffin Embedded (FFPE) Tissue Sections”
PLoS One, 2017.
DOI: 10.1371/journal.pone.0176691


 



F. Paratore, T. Zeidman Kalman, T. Rosenfeld, G.V. Kaigala, M. Bercovici
“Isotachophoresis-Based Surface Immunoassay”
Analytical Chemisty 89(14), 7373–7381, 2017.
DOI: 10.1021/acs.analchem.7b00725


X.F. van Kooten, M. Truman-Rosentsvit, G.V. Kaigala, M. Bercovici
“Focusing analytes from 50 ìL into 500 pL. On-chip focusing from large sample volumes using isotachophotoresist”
Scientific Reports 7, 2017.
DOI: 10.1038/s41598-017-10579-5